Yung-Hua Li

Associate Professor





Phone: 902-494-3063
Mailing Address: 
Department of Applied Oral Sciences
Dalhousie University
Dentistry Building, Room 5215,
5981 University Avenue
PO Box 15000
Halifax Nova Scotia Canada B3H 4R2
Research Topics:
  • Biofilm ecology
  • cell-cell communication
  • Bacterial stress response
  • Antibiotic resistance mechanisms
  • Oral microbiomes


DMD: Wuhan University
MSc: University of Manitoba
PhD: University of Manitoba
Postdoctoral Training: University of Rochester, University of Toronto

Research interests

My laboratory, the “Biofilm Laboratory”, focuses on molecular dissection of bacterial biofilms and pathogenesis, largely involving studies of bacterial genomes, genes and gene products important for biofilm formation, stress response, cell-cell communication, antibiotic resistance and pathogenesis. My research is currently funded by CIHR and NSERC.

Selected publications

For a complete list of Dr. Yung-Hua Li's publications, click here.

  • Dong GF, Tian XL, Liu TL, Cyr K, Chen C, Lin W. German M, Li YH. 2016. Structural and functional insights into the ComD histidine protein kinase, a quorum sensing signalling peptide receptor of Streptococcus mutans. Scientific Report. 6:26502 | DOI: 10.1038/srep26502

  • Jalal N, Tian XL, Dong GF, Upham J, Chen C. Parcells M, LI YH. 2015. Identification and characterization of SMU.244 encoding a putative UppP protein required for the cell wall biosynthesis and bacitracin resistance in Streptococcus mutans. Microbiology. 161: 1857-1870 Doi: 10.1099/mic.0.000142.

  • Dong GF, Tian XL, Gomez ZA, Li YH. 2014. Regulated proteolysis of the alternative sigma factor SigX in Streptococcus mutans: implication in the escape from competence. BMC Microbiology. 14: 183 (1-16).

  • Tian XL, Dong GF, Liu TL, Gomez Z, Wahl A, Hols P, Li YH. 2013. MecA protein acts as a negative regulator of genetic competence in Streptococcus mutans. J. Bacteriology. 195:5196-5206.

  • Mai J, Tian XL, Gallant JW, Merkley N, Biswas Z, Syvitski R, Douglas SE, Ling JQ, Li YH. 2011. A novel target-specific, salt-resistant antimicrobial peptide against the cariogenic pathogen Streptococcus mutans. Antimicrob. Agents Chemother. 55: 5205-5213.


MICI 3119: Physiology of Prokaryotic cells
MICI 3620.03: Experiential Learning in Microbiology and Immunology
MICI 4900 X/Y: Honor Research Project and Thesis
DEHY 2850.03 (MICI 1200.3): Introduction to General and Oral Microbiology
DENT 1118.01 (MICI 1200.3B): Infectious Diseases
PERI 5100.06: Basic Sciences in Graduate Periodontics

Selected awards and honours

CIHR-NS Partnership New Investigator Salary Support Award

Memberships, Service and Activities

American Society for Microbiology (ASM)
Canadian Society for Microbiologists (CSM)
Dalhousie Infectious Disease Research Alliance (DIDRA)
The Dalhousie Senate Academic Program and Research Committee (2013-16)
The Research Development Committee, Faculty of Dentistry (2008-13)
The Tenure and Promotion Committee, Faculty of Dentistry (2010-2015)
The AOS New Faculty Recruitment Committee, Faculty of Dentistry (2009, 2015)
A member of CIHR Heath Professional Awards Committee – Fellowship (2013-15)
An invited reviewer of NSERC Discovery Grant Selection Committees (2012-14)
A member of CIHR Health Professional Awards - New Investigator Award (2011)
A member of NSERC Grant Selection Committee, GSC-32/GSC-1511 (2008-10)
An invited reviewer of CIHR Grant Review Committee – Dental Sciences (2008-09)
An invited reviewer of CIHR Grant Review Committee – Experimental Medicine (2007)

Office Hours

8.30 am – 4.30 pm from Monday to Friday