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Alyson KelvinPhD

Division of Pediatric Infectious Diseases, Assistant Professor

Department of Pediatrics , Department of Microbiology & Immunology

Email: akelvin@dal.ca
Mailing Address: 
Division of Infectious Diseases
IWK Health Centre, Goldbloom Building, R4020
5850/5980 University Ave.
PO Box 9700

 
Research Topics:
  • Influenza virus
  • Zika virus
  • Viral pathogenesis
  • Viral transmission
  • Host response
  • Host-Pathogen interation
  • Immune Imprinting
  • Immune Memory

Education

  • Honours BSc (Western University)
  • PhD (Queen’s University, Belfast)
  • PDF (University Health Network)

Research interests

My research investigates the intersection of host age and previous infection in the context of influenza infection and vaccination. I use animal models, in vitro systems, and patient samples to obtain a picture of disease and its mechanisms. I recently discovered that lactating mammary glands are susceptible to influenza infection.

Selected publications

  • Paquette SG, Banner D, Huang SS, Almansa R, Leon A, Xu L, Bartoszko J, Kelvin DJ, and Kelvin AA*. Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses. PLoS Pathogens 2015 Oct;11(10):e1005173
  • Kelvin AA*, Degousee N, Banner D, Stefanski E, Leomicronn AJ, Angoulvant D, Paquette SG, Huang SS, Danesh A, Robbins CS, Noyan H, Husain M, Lambeau G, Gelb M, Kelvin DJ, and Rubin BB. Lack of group X secreted phospholipase A(2) increases survival following pandemic H1N1 influenza infection. Virology 2014 Apr;454-455:78-92. PMCID:PMC4106042
  • Paquette SG, Banner D, Chi le TB, Leomicronn AJ, Xu L, Ran L, Huang SS, Farooqui A, Kelvin DJ, and Kelvin AA*. Pandemic H1N1 influenza A directly induces a robust and acute inflammatory gene signature in primary human bronchial epithelial cells downstream of membrane fusion. Virology 2014 Jan 5;448:91-103
  • Huang SS, Lin Z, Banner D, Leon AJ, Paquette SG, Rubin B, Rubino S, Guan Y, Kelvin DJ, and Kelvin AA*. Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure. Scientific Reports 2013;3:1698. PMCID:PMC3633051
  • Huang SS, Banner D, Degousee N, Leon AJ, Xu L, Paquette SG, Kanagasabai T, Fang Y, Rubino S, Rubin B, Kelvin DJ and Kelvin AA*. Differential pathological and immune responses in newly weaned ferrets are associated with a mild clinical outcome of pandemic 2009 H1N1 infection. Journal of Virology 2012 Dec;86(24):13187-201. PMCID:PMC3503035
  • View additional publications on PubMed

The underlined individuals are those I have directly mentored. The asterisk (*) indicates that I was responsible for the study inception, design, operations, analysis, and publication.

Selected awards and honours

  • My work has been featured on This Week In Virology with Vincent Racaniello. TWiV 363: Eat flu and dyad. http://www.twiv.tv/2015/11/15/twiv-363/
  • My work was featured on the Virology Blog.  All about viruses and disease. Influenza virus in breast milk. http://www.virology.ws/2015/11/12/influenza-virus-in-breast-milk/
  • Dorothy Price Prize recipeint, Immunology Master Class 2006 from the Irish Society of Immunology
  • Overseas Research Studentship (ORS) recipient, 2004-2007. British Federal Government, UK
  • Faculty of Medicine and Health Sciences PhD Studentship recipient, 2003 – 2006. Queen's University, Belfast, UK

Memberships

  • CIHR College of Reviewers
  • Canadian Society for Virology
  • American Society for Virology
  • American Society for Microbiology

Teaching

  • Visiting Professor, University of Sassari, Sassari (Italy), Biomedical Science for 3rd year Medical Students (2009-2010)

Service & activity

  • Associate Editor, Journal of Infection in Developing Countries (2010-)