Dal Alert!

Receive alerts from Dalhousie by text message.

X

Ryan Pelis

Associate Professor

Pharmacology_Ryan_Pelis
Department of Pharmacology

Email: ryan.pelis@dal.ca
Phone: 902-494-6058
Mailing Address: 
Room 5B1, Sir Charles Tupper Medical Building, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Pharmacology
  • Pharmacokinetics
  • Pharmacokinetic modeling
  • Drug interactions
  • Membrane transport
  • Transport kinetics
  • Protein structure and function

Education

  • BSc (University of Massachusetts)
  • MSc (University of Massachusetts)
  • PhD (University of Connecticut)

Research interests

Our research focuses on the impact that epithelial drug transport plays in regulating tissue-drug concentrations, and its potential involvement in drug-drug interactions and interindividual variability in drug exposure and response.

Selected awards and honours

  • 2013: Simcyp Most Innovative Teaching Award, Simcyp Limited, Sheffield, UK
  • 2006: NIH Ruth L. Kirschstein National Research Service Award
  • 2005: Research Recognition Award, American Physiological Society
  • 2004: Scholander Award, American Physiological Society

Selected publications

  • Lee J and Pelis RM. Drug transport by the blood-aqueous humor barrier of the eye. Drug Metab Dispos, 2016.
  • Hotchkiss A, Berrigan L and Pelis RM. Organic anion transporter 2 transcript variant 1 shows broad selectivity when expressed in multiple cell lines. Front in Pharmacol 6:216, 2015.
  • Hotchkiss A, Gao T, Khan U, Berrigan L, Li M, Ingraham L and Pelis RM. Organic anion transporter 1 is inhibited by multiple mechanisms and shows a transport mode independent of of exchange. Drug Metab Dispos 43:1847-54, 2015.
  • Lee J, Shahidullah M, Hotchkiss A, Coca-Prados M, Delamere NA and Pelis RM. A renal-like organic anion transport system in the ciliary epithelium of the eye.Mol Pharmacol87: 697-705, 2015.
  • Ingraham L, Li M, Renfro JL, Parker S, Vapurcuyan A, Hanna Iand Pelis RM. A plasma concentration ofa-ketoglutarateinfluences the kinetic interaction of ligands with OAT1.Mol Pharmacol86: 86-95, 2014.