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A prospective cohort study of the feasibility and efficacy of iron reduction by phlebotomy in recipients of hematopoietic SCT (Letter to Editor)

Posted by Sharon Clarke and Steve Burrell on December 15, 2014 in Abdominal

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Transfusional iron overload is common in hematopoietic SCT (HSCT) patients and is a potential cause of morbidity and mortality. Iron overload, estimated by increased ferritin, appears to be associated with adverse outcomes and decreased survival.1, 2, 3, 4

There are several unanswered questions in this area. First, it is not clear how to best measure iron overload in these patients. Second, the exact mechanism whereby iron overload causes increased mortality has not been definitively established. Finally, the impact of reducing iron and the best method to achieve iron reduction in these patients are unknown.


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