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Denis Dupré

Associate Professor

Pharmacology_Denis_Dupre

Related information

Department of Pharmacology

Email: denis.dupre@dal.ca
Phone: 902-494-2550
Mailing Address: 
Room 6C, Sir Charles Tupper Medical Building, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Pharmacology
  • G protein coupled receptor
  • Cancer
  • Cardiovascular
  • Signaling
  • Trafficking
  • Dimerization
  • Immunology

Education

  • BSc (Université de Sherbrooke)
  • PhD (Université de Sherbrooke)
  • PDF (Montreal Heart Institute/McGill University)

Research interests

In our lab, we study how G protein coupled receptors are involved in diseases like cancer or heart diseases. Many different therapies block GPCRs signaling at the cell surface but sometimes cause side effects. Our goal is to understand how the receptors get expressed to the cell surface where they cause the disease. We identify new ways to block receptor expression, trafficking or assembly with specific proteins to regulate how GPCRs function and participate in diseases. One of our goals is to identify new targets to block cancer metastasis.

Selected publications

  • Gillies K, Wertman J, Charette N, Dupré DJ, Anterograde trafficking of CXCR4 and CCR2 homo and heterodimers in a prostate cancer cell line. Cell Physiology and Biochemistry, 2013 Jul 5;32(1):74-85
  • Kuang YQ, Charette N, Frazer J, Holland PJ, Attwood KM, Dellaire G, Dupré DJ, Dopamine receptor interacting protein 78 acts as a molecular chaperone for chemokine receptors signaling complex organization. PLoS ONE, 2012 7(7): e40522
  • Kuang YQ, Pang W, Zheng YT, Dupré DJ: NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. European Journal of Immunology, 2012 Feb;42(2):299-310
  • Charette N, Holland P, Frazer J, Allen H, Dupré DJ: Dependence on Different Rab GTPases for the Trafficking of CXCR4 and CCR5 Homo or Heterodimers Between the Endoplasmic Reticulum and Plasma Membrane in Jurkat Cells. Cellular Signalling (2011) 23, 1738–1749
  • Hammad MM, Kuang YQ, Yan R, Allen H, Dupré DJ. NA+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction, but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer. Journal of Biological Chemistry 2010 Nov 5; 285(45):34653–34664

Selected awards and honours  

  • CIHR New Investigator Award
  • DMRF New Investigator Award