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James Fawcett

Professor

Pharmacology_James_Fawcett

Related information

Department of Pharmacology

Email: jim.fawcett@dal.ca
Phone: 902-494-3659
Mailing Address: 
Dept of Pharmacology, Tupper Medical Bldg, 5850 College St, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Pharmacology
  • Cell polarity
  • Proteomics
  • Molecular neurobiology
  • Neurodevelopment
  • Schizophrenia
  • Cancer

Education

  • BSc (McMaster)
  • MSc (McMaster)
  • MSc(T) (McMaster)
  • PhD (McGill)
  • PDF (Toronto)

Research interests

The Fawcett Lab is interested in developmental neurobiology with an emphasis on intracellular signaling complexes underlying neuronal polarity. We utilize molecular and cellular approaches, combined with mass spectrometry based screens to characterize protein complexes involved in establishing neuronal polarity and synapse development.

Selected publications  

  • Richier, L., Williton, K., Clattenburg, L., Colwill, K., O'Brien, M., Tsang, C., Kolar, A., Zinck, N., Metalnikov, P., Trimble, W.S., Krueger, S., Pawson, T.*, Fawcett, J.P.,* (2010) NOS1AP associates with Scribble and regulates dendritic spine development. J. Neurosci. 30:4796-4805.
  • Fawcett, J.P., Georgiou, J., Ruston, J., Bladt, F., Sherman, A., Warner, N., Saab, B.J., Scott, R., Roder, J.C. Pawson, T. (2007) "Nck adaptor proteins control the organization of neuronal circuits important for walking". PNAS 104:20973-20978.
  • Wells C*, Fawcett, J.P.*, Traweger A., Yamanaka, Y., Goudreault, M., Elder, K., Kulkarni, S., Gish, G., Virag, C., Lim C., Colwill C., Starostine, A., Metalnikov, P., Pawson, T. (2006) "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells". Cell 125:535-548.

Selected awards and honours  

  • Canadian Research Chair Tier 2 (2006-2016)
  • Barbara Turnbull Award Winner 2010 (CIHR)
  • Maud Menten Prize Award 2010 (CIHR-Institute of Genetics)
  • EJLB Foundation Scholar