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Susan Howlett

Professor

Pharmacology_Howlett_photo1
Department of Pharmacology , Division of Geriatric Medicine

Email: susan.howlett@dal.ca
Phone: 902-494-3552
Mailing Address: 
Room 6D, Sir Charles Tupper Medical Building, 5850 College Street, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Aging
  • Frailty
  • Hormonal regulation of cardiac function
  • Estrogen
  • Cardiac excitation-contraction coupling
  • Myocardial ischemia and reperfusion
  • Patch voltage clamp
  • Calcium imaging

Education

  • BSc (Concordia University)
  • MSc (Memorial University of Newfoundland)
  • PhD (Memorial University of Newfoundland)
  • PDF (University of Alberta)

Research interests

Dr. Howlett is best known for her work on cardiac contraction. She has discovered profound differences in the way male and female heart cells function and how this changes with age. She has pioneered the measurement of frailty with a "frailty index" in aging animals, a major advance that will help translate scientific discoveries in aging research into meaningful clinical interventions.

Selected publications

  • Feridooni HA, MacDonald JK, Ghimire A, Pyle WG, Howlett SE.  Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart.  Am J Physiol, 312:H46-59, 2017. 
  • Rockwood K, Blodgett JM, Theou O, Sun MH, Feridooni HA, Mitnitski A, Rose RA, Godin J, Gregson E, Howlett SE.  A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice.  Sci Reports, 7:43068, 2017.
  • Jansen HJ, Moghtadaei M, Mackasey M, Rafferty SA, Bogachev O, Sapp JL, Howlett SE, Rose RA.  Atrial structure, function and arrhythmogenesis in aged and frail mice.  Sci Reports, 7:44336, 2017.
  • Feridooni H, Kane AE, Boroumandi A, Polidovitch N, Rose RA, Tsushima R, Howlett SE.  The impact of age and frailty on ventricular structure and function in C57BL/6 mice. J Physiol (Lond), in press, 2017.
  • Whitehead JC, Hildebrand BA, Rockwood MR, Rose RA, Rockwood K, Howlett SE.  A clinical frailty index in aging mice:  comparisons with frailty index data in humans.  J Gerontol A Biol Sci Med Sci, 69:621-32, 2014.