Axonal Transport and Neuron‑Glia Interaction
Investigating root causes
One of the earliest signs of glaucoma is disruption in the axonal transport of nutrients to and from retinal ganglion cells.
Since these nutrients are required for healthy eye function, we’re interested in understanding exactly how and why the axonal transport becomes disrupted. We’re also exploring the role of astrocytes, the most numerous neuroglial cells in the central nervous systems, and the key modulators of axonal health.
As a part of this research project, we use a variety of methods to:
- visualize transport
- measure the activity of astrocytes
- mathematically model transport disruption