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Use of Cannabinoids to Reduce Joint Nerve Damage and Prevent Osteoarthritis Pain

PI: Jason J. McDougall

We have recently discovered that the peripheral nervous system becomes damaged during osteoarthritis, which can lead to a distinct type of pain called neuropathic pain. We are testing to see if cannabinoids can reverse this neuropathology to help uncover a whole new therapeutic approach to controlling osteoarthritis pain.

[Project funded by The Arthritis Society of Canada].


Nerve cell bodies from normal animal
Nerve cell bodies from arthritic
animal showing nerve damage

Transmission electron micrograph of
saphenous nerve from normal animal
Transmission electron micrograph of
saphenous nerve from arthritic animal
showing loss of myelination