Lindsay Wallace, PhD

Research topics

• Dementia
• Frailty
• Epidemiology
• Public Health
• Population Health
• Healthy Aging & Aging Trajectories
• Chronic Disease

Education

• Post-doctoral fellowship (Public Health) University of Cambridge, UK
• PhD (Interdisciplinary Studies) Dalhousie University, Canada
• MSc (Integrated Program in Neuroscience) McGill University, Canada
• BSc (Psychology) Dalhousie University, Canada

Research interests

The focus of Dr. Wallace’s research is understanding the physical, social, and structural conditions that give rise to chronic disease, and how we can implement scalable solutions to reduce morbidity. The majority of her research to date has examined the interplay between frailty and dementia in this context. Dr. Wallace’s work is inherently interdisciplinary and blends insights from epidemiology, public health, and neuroscience to address the complexity of aging and disease. She analyses data from large longitudinal cohort studies to support her research, as well as using interventional techniques and policy analysis.

Selected publications

• Mukadam N, Wolters FJ, Walsh S, Wallace L, Brayne C, Matthews FE, Sacuiu S, Skoog I, Seshadri S, Beiser A, Ghosh S. Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies. The Lancet Public Health. 2024 Jul 1;9(7):e443-60.
• Ward DD, Flint J, Littlejohns T, Foote I, Canevelli M, Wallace L, Gordon E, Llewelyn D, Ranson J, Hubbard R, Rockwood K, Stolz E. Frailty trajectories preceding dementia: an individual level analysis of four cohort studies in the United States and United Kingdom. JAMA Neurology, 2024
• Walsh S, Wallace L, Merrick R, Hayat S, Luben R, Mytton O, Lafortune L, Brayne C. How many future dementia cases would be missed by a high-risk screening programme? A retrospective cohort study in a population-based cohort, Alz Dem, 2024;20(9):6278-6286.
• Walsh S, Wallace L, Kuhn I, Mytton O, Lafortune L, Wills W, Mukadam N, Brayne C. Population-level interventions for the primary prevention of dementia: a complex evidence review. The Lancet. 2023 Nov 1;402:S13.
• Theou O, Haviva C, Wallace L, Searle SD, Rockwood K. How to construct a frailty index from an existing dataset in 10 steps. Age and Ageing. 2023 Dec 1;52(12):afad221.
• Wallace L, Theou O, Darvesh S, Bennett DA, Buchman AS, Andrew MK, Kirkland SA, Fisk JD, Rockwood K. Neuropathologic burden and the degree of frailty in relation to global cognition and dementia. Neurology. 2020 Dec 15;95(24):e3269-79.
• Wallace L, Squires E, Rockwood K, Andrew M, Theou O. Validation of the Pictorial Fit-Frail Scale in a memory clinic setting. International Psychogeriatrics, 2019
• Wallace L, Theou O, Godin J, Andrew MK, Bennett DA, Rockwood K. Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project. The Lancet Neurology. 2019 Feb 1;18(2):177-84.
• Wallace L, Theou O, Pena F, Rockwood K, Andrew M. Social vulnerability as a predictor of mortality and disability: Cross-country differences in the Survey of Health, Aging, and Retirement in Europe (SHARE). Aging Clinical and Experimental Research, 2014;1-8.

Selected awards & honours

• Canadian Institutes of Health Research Fellowship Prize of Excellence in Research on Aging (2020)
• Canadian Tri-council Banting Postdoctoral Fellowship (2020)
• Dalhousie Prize for best doctoral thesis submitted in 2020 by students in Engineering, Medical, and Natural Sciences (2021)
• Mitacs Globalink Award (2018)
• Canadian Institutes of Health Research Doctoral Award (2017)
• Alzheimer Society of Canada Doctoral Award (2015)

Service

• Co-Principal Investigator, Canadian Longitudinal Study on Aging (CLSA) Dalhousie/Halifax site; 2025- present
• Peer review committee member, CIHR Doctoral Research Award Program; 2022/23, 2024/25