Denys Khaperskyy

Assistant Professor

Khaperskyy2

Laboratory website

Currently recruiting for an MSc candidate

 


Email: d.khaperskyy@dal.ca
Phone: (902) 494-1086
Lab: (902) 494-3883
Research Topics:
  • Host-pathogen interaction
  • Influenza A virus
  • Cellular stress responses
  • RNA granules

Education

BSc: National Taras Shevchenko University, Kyiv, Ukraine
PhD: State University of New York at Buffalo, Buffalo, NY
Postdoctoral Training: Dalhousie University, Halifax, NS

Research interests

We study virus-host interactions with a focus on intrinsic cell defense mechanisms and their subversion by influenza viruses. Another area of interest in the lab is the biology of stress granules – cytoplasmic foci of messenger RNA-protein complexes that form in response to various types of stress, including viral infections

Selected publications

For a full list of Dr. Khaperskyy's publications, click here.

McCormick, C. and Khaperskyy, D.A. (2017) Translation inhibition and stress granules in the antiviral immune response. Nat. Rev. Immunol. 10:647-660.

Khaperskyy, D.A., Schmaling, S., Larkins-Ford, J., McCormick, C., and Gaglia, M.M. (2016) Selective degradation of host RNA polymerase II transcripts by influenza A virus PA-X host shutoff protein. PLoS Pathog. 12: e1005427.

Khaperskyy, D.A., Emara, M. M., Johnston, B.P., Anderson, P., Hatchette, T.F., and McCormick, C. (2014) Influenza A virus host shutoff disables antiviral stress-induced translation arrest. PLoS Pathog. 10: e1004217.

Khaperskyy, D.A., Hatchette, T.F., and McCormick, C. (2012) Influenza A virus inhibits cytoplasmic stress granule formation. FASEB J. 26: 1629-39.

Teaching

  • MICI 4114 Advanced virology
  • MICI 3620 Experiential learning