Andrew Makrigiannis

Education

BSc (Honours), Dalhousie University
PhD, Dalhousie University
Post-doctoral Training, National Cancer Institute - Frederick (NIH)

Research Interests

Dr. Makrigiannis’ research focus is the innate immune system, and in particular Natural Killer (NK) cell recognition of virally-infected or cancerous cells via the polymorphic Ly49 family of class I MHC receptors and the related NKR-P1 receptor family, in order to understand the contribution of NK cell receptors to diseases for translation into clinical therapies.

Selected publications

For a complete list of Dr. Andrew Makrigiannis' publications, click here

Mir Munir A. Rahim, Brendon D. Parsons, Emma L. Price, Patrick D. Slaine, Becca L. Chilvers, Gregory S. Seaton, Andrew Wight, Daniel Medina-Luna, Sayanti Dey, Shannen L. Grandy, Lauryn E. Anderson, Natalia Zamorano Cuervo, Nathalie Grandvaux, Marta M. Gaglia, Alyson A. Kelvin, Denys A. Khaperskyy, Craig McCormick*, Andrew P. Makrigiannis*, Defective Influenza A Virus RNA Products Mediate MAVS-Dependent Upregulation of Human Leukocyte Antigen Class I Proteins, The Journal of Virology, Volume 94, Issue 13, e00165-20 (July 2020) (* denotes co-corresponding authors)

PMID: 32321802

Wight Andrew, Mahmoud Ahmad Bakur, Scur Michal, Tu Megan M, Rahim Mir Munir A, Sad Subash, Makrigiannis Andrew P, Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses, Proceedings of the National Academy of Sciences of the United States of America, Volume 115, Issue 45, 11579-11584 (September 24, 2018)

PMID: 30249666

Aguilar Oscar A, Berry Richard, Rahim Mir Munir A, Reichel Johanna J, Popović Branka, Tanaka Miho, Fu Zhihui, Balaji Gautham R, Lau Timothy N H, Tu Megan M, Kirkham Christina L, Mahmoud Ahmad Bakur, Mesci Aruz, Krmpotić Astrid, Allan David S J, Makrigiannis Andrew P*, Jonjić Stipan*, Rossjohn Jamie*, Carlyle James R*, A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family, Cell, Volume 169, Issue 1, 58-71.e14 (March 23, 2017) (* denotes co-corresponding authors)

PMID: 28340350

Mahmoud Ahmad Bakur, Tu Megan M, Wight Andrew, Zein Haggag S, Rahim Mir Munir A, Lee Seung-Hwan, Sekhon Harman S, Brown Earl G, Makrigiannis Andrew P, Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion, PLoS pathogens, Volume 12, Issue 2, e1005446 (February 29, 2016)

PMID: 26928844

Rahim Mir Munir A, Chen Peter, Mottashed Amelia N, Mahmoud Ahmad Bakur, Thomas Midhun J, Zhu Qinzhang, Brooks Colin G, Kartsogiannis Vicky, Gillespie Matthew T, Carlyle James R, Makrigiannis Andrew P, The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses, Blood, Volume 125, Issue 14, 2217-27 (January 22, 2015)

PMID: 25612621

Tu Megan M, Mahmoud Ahmad Bakur, Wight Andrew, Mottashed Amelia, Bélanger Simon, Rahim Mir Munir A, Abou-Samra Elias, Makrigiannis Andrew P, Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells, Cancer research, Volume 74, Issue 14, 3684-94 (May 6, 2014)

PMID: 24802191

Bélanger Simon, Tu Megan M, Rahim Mir Munir Ahmed, Mahmoud Ahmad B, Patel Rajen, Tai Lee-Hwa, Troke Angela D, Wilhelm Brian T, Landry Josette-Renée, Zhu Qinzhang, Tung Kenneth S, Raulet David H, Makrigiannis Andrew P, Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice, Blood, Volume 120, Issue 3, 592-602 (June 1, 2012) (Highlighted by the Faculty of 1000)

PMID: 22661698

Tai Lee-Hwa, Goulet Marie-Line, Belanger Simon, Toyama-Sorimachi Noriko, Fodil-Cornu Nassima, Vidal Silvia M, Troke Angela D, McVicar Daniel W, Makrigiannis Andrew P, Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC, The Journal of experimental medicine, Volume 205, Issue 13, 3187-99 (December 15, 2008)

PMID: 19075287

Carlyle James R, Mesci Aruz, Fine Jason H, Chen Peter, Bélanger Simon, Tai Lee-Hwa, Makrigiannis Andrew P, Evolution of the Ly49 and Nkrp1 recognition systems, Seminars in immunology, Volume 20, Issue 6, 321-30 (July 2, 2008)

PMID: 18595730

Colina Rodney, Costa-Mattioli Mauro, Dowling Ryan J O, Jaramillo Maritza, Tai Lee-Hwa, Breitbach Caroline J, Martineau Yvan, Larsson Ola, Rong Liwei, Svitkin Yuri V, Makrigiannis Andrew P, Bell John C, Sonenberg Nahum, Translational control of the innate immune response through IRF-7, Nature, Volume 452, Issue 7185, 323-8 (February 13, 2008)

PMID: 18272964

Teaching

MICI 2100: Introductory Microbiology and Immunology

Memberships, Services and Activities

-       Senior Scientist - Beatrice Hunter Cancer Research Institute

-       Member – Canadian Society for Immunology

-       Member – Society for Natural Immunity

Selected awards and honours

2014                          Canada Research Chair, Tier II 

2009                          Canada Research Chair, Tier II 

2006                          Canadian Society for Immunology New Investigator Award 

2003                          CIHR New Investigator Salary Support Award 

Office Hours

Please make an appointment with Mary Ellen Doolittle
(click to email mary.ellen.doolittle@dal.ca)