Professor and Head of Department
Sir Charles Tupper Medical Building, Room 7-C2
5850 College Street
PO Box 15000
Halifax, Nova Scotia Canada B3H 4R2
- Natural Killer Cell Biology
- MHC receptors
- NK cell Memory
- Innate Immunity
- Infectious Disease
BSc (Honours), Dalhousie University
PhD, Dalhousie University
Post-doctoral Training, National Cancer Institute - Frederick (NIH)
Dr. Makrigiannis’ research focus is the innate immune system, and in particular Natural Killer (NK) cell recognition of virally-infected or cancerous cells via the polymorphic Ly49 family of class I MHC receptors and the related NKR-P1 receptor family, in order to understand the contribution of NK cell receptors to diseases for translation into clinical therapies.
Mahmoud AB, Tu MM, Zein H, Ahmed Rahim MM, Abou-Samra E, Sekhon H, Gomes M, Sentman CL, Lee SH, Brown EG, and Makrigiannis AP. Influenza virus targets class I MHC-educated NK cells for immunoevasion. PLOS Pathogens. (Accepted).
Rahim MM and Makrigiannis AP. Ly49 receptors: evolution, genetic diversity, and impact on immunity. Immunol. Reviews. 2015 Sept; 267(1):137-147. (invited review)
Rahim MM, Chen P, Mottashed AN, Mahmoud, AB, Thomas MJ, Zhu Q, Brooks CG, Kartsogiannis V, Gillespie MT, Carlyle JR*, and Makrigiannis AP*. The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses. Blood. 2015 Jan; 125(14):2217-27. *co-corresponding authors
Tu MM, Mahmoud AB, Wight A, Mottashed A, Bélanger S, Rahim MM, Abou-Samra E, and Makrigiannis AP. Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 2014 Jul; 74(14):3684-94.
McFall E, Tu MM, Al-Khattabi N, Tai LH, St-Laurent AS, Tsankova V, Hall CW, Belanger S, Troke AD, Wight A, Mahmoud AB, Zein HS, Rahim MM, Carlyle JR, and Makrigiannis AP. Optimized tetramer analysis reveals Ly49 promiscuity for MHC ligands. J. Immunol. 2013 Dec; 191(11):5722-9.
Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, and Makrigiannis AP. Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner. J. Immunol. 2013 Apr; 190(8):3994-4004.
Bélanger S, Tu MM, Rahim MM, Mahmoud AB, Patel R, Tai L-H, Troke AD, Wilhelm BT, Landry J-R, Zhu Q, Tung KS, Raulet DH, and Makrigiannis AP. Impaired natural killer cell self-education and ‘missing-self’ responses in Ly49-deficient mice. Blood. 2012 Jul; 120(3):592-602. (Cited by the Faculty of 1000 as an article of special significance)
Tai L-H, Goulet M-L, Bélanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, and Makrigiannis AP. Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J. Exp. Med. 2008 Dec; 205(13):3187-99.
Colina R, Costa-Mattioli M, Dowling RJO, Tai L-H, Jaramillo M, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitki YV, Makrigiannis AP, Bell JC, and Sonenberg N. Translational control of the innate immune response via IRF-7. Nature. 2008 Mar; 452(7185):323-8.
MICI 2100: Introductory Microbiology and Immunology
Memberships, Services and Activities
- Senior Scientist - Beatrice Hunter Cancer Research Institute
- Member – Canadian Society for Immunology
- Member – Society for Natural Immunity
Selected awards and honours
2014 Canada Research Chair, Tier II
2009 Canada Research Chair, Tier II
2006 Canadian Society for Immunology New Investigator Award
2003 CIHR New Investigator Salary Support Award
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