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John Rohde

Assistant Professor

john rohde1a-2

 

Related information:

 

Department of Microbiology & Immunology

Email: john.rohde@dal.ca
Phone: 902-494-7819
Fax: 902-494-5125
Mailing Address: 
Department of Microbiology and Immunology
Dalhousie University
Sir Charles Tupper Medical Building, Room 7G
5850 College Street
PO Box 15000
Halifax Nova Scotia Canada B3H 4R2
 
Research Topics:
  • Bacteriology
  • Inflammation
  • Microbial Pathogenesis
  • Shigella Flexneri
  • Ubiquitin
  • Signal Transduction
  • Type 3 Secretion Systems

Education

BS Bacteriology and Biochemistry, University of Idaho
MS Bacteriology and Biochemistry, University of Idaho
PhD Biochemistry and Molecular Biology, University of British Columbia
Postdoctoral Training: Duke Medical Center, Institut Pasteur, Samuel Lunenfeld
Research Institute, Mt. Sinai Hospital

Research interests

The focus of the Rohde lab is to understand the mechanisms by which the bacterium, Shigella spp., causes disease. We are especially interested in how pathogens hijack the ubiquitin proteasome system. Our lab is also developing genetic tools to facilitate the study of virulence at a systems level.

Selected publications

  • Onodera NT, Ryu J, Durbic T, Nislow C, Archibald JM, Rohde JR. 2012. Genome Sequence of Shigella flexneri Serotype 5a Strain M90T Sm. J Bacteriol.  194(11):3022.·      
  • Chou YC, Keszei AF, Rohde JR, Tyers M, Sicheri F. 2012 Conserved structural mechanisms for auto-inhibition in IpaH ubiquitin ligases. J Biol Chem. 287(1):268-75.
  • Singer AU , Rohde JR, Lam R, Skarina T, Kagan O, DiLeo R, Chirgadze NY, Tyers M, Sansonetti PJ, Parsot C, and A. Savchenko.  Structure of the Shigella type III secretion effector IpaH defines a novel class of E3 ubiquitin ligases. Nat Struct Mol Biol. 15(12):1293-301.
  • Rohde JR, A. Breitkreutz, A. Chenal, PJ Sansonetti, and C. Parsot, 2007. Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host and Microbe 1 (1):77-83.