Department of Microbiology & Immunology

Faculty of Medicine

Patrick Lee

Professor, Retired

Department of Microbiology & Immunology

Email: patrick.lee@dal.ca
Research Topics:
  • Cancer Biology
  • Immunology
  • Virology
  • Reovirus
  • Oncolytic Viruses
  • Tumour Suppressors
  • P53 and Alzheimer's Disease
  • Oncogenes

 

Education

BSc, University of Alberta
PhD, University of Alberta
Postdoctoral Training, Duke University

Research interests

A major research project in Professor Lee’s laboratory involves the use of viruses as anti-cancer agents. His team studies reovirus, a naturally occurring human virus that is undergoing phase I/II and III clinical trials internationally. Another project focuses on the tumor suppressor protein p53 and its link to Alzheimer’s Disease.

Selected publications

  • Clements D, Sterea A, Kim Y, Helson E, Dean C, Nunokawa A, Coyle K, Shariff T, Marcato P, and Gujar S* and Lee P. 2015. Newly recruited CD11b+, GR-1+, Ly6Chigh myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus. Journal of Immunology. Mar 30. pii: 1402132. [Epub ahead of print] (*co-corresponding author).
  • Garant K, Ahn D, Shmulevitz M, Pan L, Daigle RM, Gujar S* and Lee PWK. 2015. Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release. Accepted in Oncogene. (*co-corresponding author).
  • Ahn D, Chisholm K, Pinto D, Sharif T, Gujar S* and Lee P. 2015. Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response. Accepted in Cell Cycle. (*co-corresponding author).
  • Gujar S, Clements D*, Delong R, Helson E, Marcato P and Lee P. 2014. Gemcitabine Potentiates Reovirus-induced Anti-Tumor Immune Activities and Enhances the Efficacy of Oncotherapy. British Journal of Cancer. 110:83-93. (*co-first author)
  • View additional publications on PubMed

Selected awards and honours

  • 2000                 University of Alberta Alumni Honour Award    
  • 2002                 Named “University Professor”, University of Calgary
  • 2003                 Celebration of Excellence Award, University of Calgary
  • 2003-present    Cameron Chair in Cancer Research, Dalhousie University
  • 2010                 Professional of Distinction Award: Discovery Centre for Science and                                             Technology