Beata Derfalvi, MD, PhD
Division Head of Pediatric Immunology, Professor
Email: beata.derfalvi@iwk.nshealth.ca
Phone: 902-470-8491
Fax: 902-470-7812
Mailing Address:
IWK Health Centre
PO Box 9700
5850-5980 University Ave.
Halifax, NS B3K 6R8
Dr. Beata Derfalvi is a pediatric immunologist at the IWK Health Centre, Professor of Pediatrics and Head of the Division of Immunology at Dalhousie University in Halifax. She graduated, completed pediatric residency, clinical immunology and rheumatology fellowships and Ph.D. in Immunology at Semmelweis University Budapest, Hungary. She joined Dalhousie University in 2013.
Dr. Derfalvi served as the Immunology Section Lead at the Canadian Allergy and Immunology Society (2019-2021), and she is currently a member of the Medical Directors at Immunity Canada patient organization and Immunodeficiency Canada. As the co-chair of the Clinical Immunology Network Canada, Inborn Errors of Immunity Registry Steering Committee, she is leading the initiative to establish a national patient registry.
Dr. Derfalvi provides care for children with inborn errors of immunity, many of whom also present with autoimmune, autoinflammatory or rheumatological diseases caused by immune dysregulation.
Research Interests:
Dr. Derfalvi’s clinical and translational research program focusses on understanding immune dysregulation in rare forms of inborn errors of immunity, and in common autoimmune inflammatory diseases, such as juvenile idiopathic arthritis.
Publications (Selected Most Recent):
- Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling. Nunes-Santos CJ, Kuehn H, Boast B, Hwang S, Kuhns DB, Stoddard J, Niemela JE, Fink DL, Pittaluga S, Abu-Asab M, Davies JS, Barr VA, Kawai T, Delmonte OM, Bosticardo M, Garofalo M, Carneiro-Sampaio M, Somech R, Gharagozlou M, Parvaneh N, Samelson LE, Fleisher TA, Puel A, Notarangelo LD, Boisson B, Casanova JL, Derfalvi B, Rosenzweig SD.Nat Commun. 2023 Jun 22;14(1):3708. doi: 10.1038/s41467-023-39272-0.PMID: 37349293 Free PMC article.
- MicroRNA-27a-3p enhances the inflammatory phenotype of Juvenile Idiopathic Arthritis fibroblast-like synoviocytes. Bullock CH, McAlpine SM, Roberts SE, Derfalvi B.Pediatr Rheumatol Online J. 2023 Jun 6;21(1):53. doi: 10.1186/s12969-023-00833-8.PMID: 37277817 Free PMC article.
- Differentially Expressed Inflammation-Regulating MicroRNAs in Oligoarticular Juvenile Idiopathic Arthritis. McAlpine SM, Roberts SE, Hargreaves BKV, Bullock C, Ramsey S, Stringer E, Lang B, Huber A, György B, Erdélyi F, Issekutz TB, Dérfalvi B.J Rheumatol. 2023 Feb;50(2):227-235. doi: 10.3899/jrheum.220160. Epub 2022 Jul 15.PMID: 35840148
- Physician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network. Suresh S, Zafack J, Pham-Huy A, Derfalvi B, Sadarangani M, McConnell A, Tapiéro B, Halperin SA, De Serres G, M Pernica J, Top KA.Allergy Asthma Clin Immunol. 2022 Apr 9;18(1):32. doi: 10.1186/s13223-022-00667-1.PMID: 35397595 Free PMC article.
- Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins. Alrumayyan N, Slauenwhite D, McAlpine SM, Roberts S, Issekutz TB, Huber AM, Liu Z, Derfalvi B.Allergy Asthma Clin Immunol. 2022 Feb 23;18(1):17. doi: 10.1186/s13223-022-00658-2.PMID: 35197125 Free PMC article.
- See PubMed for full-list of publications