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Christopher McMaster

Professor and Department Head

Pharmacology_Christopher_McMaster

Related information

Department of Pharmacology , Department of Pediatrics

Email: christopher.mcmaster@dal.ca
Phone: 902-494-3430
Mailing Address: 
Room 6B2, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Biochemical genetics
  • Eukaryotic and prokaryotic genetics
  • Inherited diseases
  • Drug target identification
  • Drug discovery
  • Metabolism

Education

  • BSc (University of Manitoba)
  • PhD (University of Manitoba)
  • PDF (Duke University Medical Center)

Research interests

Dr. McMaster's research focuses on metabolic regulation with an eye toward the development of new therapies. Areas of interest are inherited diseases and infectious diseases. Dr. McMaster has identified a potential therapy for congenital sideroblastic anemia that has entered clinical trials, and has compounds undergoing pre-clinical development for the treatment of inherited blinding disorders and infectious diseases.

Selected publications  

  • Fernandez-Murray, J.P., Prykozhij, S. Dufay, N., Steele, S., Gaston, D., Nasrallah, G., Coombs, A.J., and Liwski, R.S., Fernandez, C.V. Berman, J.N., and McMaster, C.R. (2016) Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genet. 12, e1005783
  • Robitaille, J., and McMaster, C.R. (2014) Treatment of Familial Exudative Vireoretinopathy Through S1PR2 Inhibition. US provisional patent filed May 2014; PCT CA2015/050503 filed June 15 2015.
  • Fernandez-Murray, J.P, and McMaster, C.R. (2016) Lipid Synthesis and Membrane Contact Sites: A Crossroad for Cellular Physiology. J. Lipid. Res. 57, 1778-1788
  • Gaspard, G. J., and McMaster, C.R. (2015) The Mitochondrial Quality Control Protein Yme1 is Necessary to Prevent Defective Mitophagy in a Yeast Model of Barth Syndrome. J Biol Chem. 290, 9284-98
  • Ahmed, M., Al-Khayat, A., Chioza, B.A., Fernandez-Murray, J.P., Cazenave-Gassiot, A., Wenk, M.R., Al-Salemi, F., Patton M.A., Silver, D.L., Baple, E.L., McMaster, C.R., and Crosby, A.H. (2017) A Mutation of EPT1 (SELENO1) Underlies a New Disorder of Kennedy Pathway Phospholipid Biosynthesis. Brain 140, 547-554

Selected awards and honours

  • Canada Research Chair in Biosignalling
  • Dalhousie University Student Union Award for Teaching Excellence in Graduate Studies
  • Nova Scotia Discovery Centre Innovator of the Year
  • Heart and Stroke Foundation Dr. Greg Ferrier Award
  • Medical Research Council of Canada Scholar