Andrew Stadnyk

Education

BSc Honors, University of Manitoba
PhD, McMaster University
Postdoctoral Training, Seattle Biomedical Research Institute

Research interests

Professor Stadnyk’s interests include mucosal inflammatory diseases, particularly of the digestive system.  He has contributed to understanding the processes underlying the inflammatory bowel diseases.  In the past few years his work has focused on the complement system and colitis, specifically how complement affects the interactions between epithelial cells and the microbes colonizing the intestines. More recently, he has added research into understanding the inflammation behind chemotherapy-induced mucositis, with a goal of mitigating this painful, debilitating side effect of cancer treatments.

Research Topics

• Mucosal Immunology
  
• Inflammation
• Colon cancer Biology
• Cytokines
• Epithelial Cell
• Colitis
• Anaphylatoxin
• Microbiome
• Mucositis

Selected publications

For a complete list of Dr. Stadnyk's publications, click here.  

·    George, M., Rahman, M., Connors, J., Stadnyk, A.W. Opinion: Are organoids the end of model evolution for studying host intestinal epithelium/microbe interactions? Microorganisms 7:406, 2019. https://doi.org/10.3390/microorganisms7100406

·    Fertan, E., Rodrigues, G., Wheeler, R., Goguen, D., Wong A.A., James, H., Stadnyk, A.W., Brown, R.E., Weaver, I.C.G. Cognitive decline and pro-inflammatory cytokine production are associated with cerebral-spleen tryptophan metabolism and epigenetic regulation of the Txnip gene in the 3xTg-AD mouse model. American Journal of Pathology 189:1435-1450, 2019. doi: 10.1016/j.ajpath.2019.03.006

·    Finlayson-Trick, E., Connors, J., Stadnyk, A. and Van Limbergen, J. Regulation of antimicrobial pathways by endogenous Heat Shock Proteins. Gastrointestinal Disorders 1:39–56, 2018.  doi:10.3390/gidisord1010005 http://www.mdpi.com/2624-5647/1/1/5/pdf

·    McCarthy, J., Cao, Q., Winsor, N.J., Van Limbergen, J. and Stadnyk, A.W. The anaphylatoxin C3a primes model colonic epithelial cells for expression of inflammatory mediators through G_αi. Molecular Immunology 103:125–132, 2018. doi: 10.1016/j.molimm.2018.09.008

·    Runte, C.S., Jain, U., Getz, L.J., Secord, S., Kuwae, A., Abe, A., LeBlanc, J.J., Stadnyk, A.W., Kaper, J.B., Hansen, A.-M., Thomas, N.A. Tandem tyrosine phosphosites in the enteropathogenic Escherichia coli chaperone CesT are required for differential type III effector translocation and virulence. Molecular Microbiology 108:536–550, 2018. http://dx.doi.org/10.1111/mmi.13948

Selected awards and honours

• IWK Health Centre Board of Directors: IWK Research Award 2013
• Crohn’s and Colitis Foundation of Canada: Research Leadership Award 2010

Other interests and achievements

• actively engages the lay public in discussions of science and scientific achievements
  
• recognized in 2014 as a finalist in Halifax's Discovery Centre "Science Champion” competition
• local collaborations: mucositis in pediatric cancer treatments, asparaginase treatment in pediatric ALL, oral bacteria/epithelial interactions in cancer treatments, prebiotic and probiotic use to control colitis and colon cancer
• national collaboration: International oversight committee member of the Michael J. Howorth Inflammatory Bowel Disease (IBD) Genetic, Environmental, and Microbial (GEM) Project: http://www.gemproject.ca
• international collaborations: Dr. Cordula Stover, University of Leicester, properdin and colitis; Dr. Trent Woodruff, University of Queensland, C5a and colitis