Jeanette Boudreau

Assistant Professor


Email: Jeanette.Boudreau@dal.ca
Phone: 902-494-4536
Mailing Address: 
Department of Microbiology and Immunology
Dalhousie University
Sir Charles Tupper Medical Building, Room 10-B1,
5850 College Street
PO Box 15000
Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Host defense
  • Natural killer cell biology
  • Cancer
  • Immunogenetics
  • Inflammation

Education

BSc: University of Waterloo
PhD: McMaster University
Postdoctoral Training: Memorial Sloan Kettering Cancer Center

Research interests

We investigate how human natural killer cell immunogenetics program immune responsiveness to cancer and infectious diseases. We use bioinformatics, humanized in vivo models, cell-signal analysis, and highly-parametric flow cytometry to understand how genetic variation creates diversity in human immune potentials. Our interdisciplinary and collaborative work aims to translate research findings into precision therapies.

Selected publications

For a full list of Dr. Boudreau's publications, click here.

Boudreau JE, Giglio F, Gooley TA, Stevenson PA, Le Luduec JB, Rajalinam R, Hou L, Katovich Hurley C, Lebedeva T, Noreen H, Reed EF, Yu N, Vierra-Green C, Haagenson MD, Malkki M, Petersdorf EW, Spellman S, Hsu KC. Donor KIR3DL1 and HLA-B subtype combinations predict acute myelogenous leukemia control after HLA-compatible hematopoietic cell transplantation. J Clin Oncol, 2017 Jul 10;35(20):2268-2278.

Boudreau JE, Liu XR, Zhao, Z. Shang A, Shultz LD, Greiner DL, Dupont B, Hsu KC. Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I. Immunity. 2016 Aug 16;45(2):280-91. doi: 10.10.16/j.immuni.2016.07.005.

Boudreau JE, Mulrooney TJ, Le Luduec JB, Barker E, Hsu KC. KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. J Immunol. 2016 Apr 15;196(8):3398-410. doi: 10.4049/jimmunol.1502469.

Forlenza, CJ, Boudreau JE, Zheng J, Le Luduec JB, Chamberlain E, Heller G, Cheung NK, Hsu KC. KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma. J Clin Oncol . 2016 Jul 20;34(21):2443-51. doi: 10.1200/JCO.2015.64.9558.

Boudreau JE, Le Luduec JB, Hsu KC.  Development of a novel multiplex PCR assay to detect functional subtypes of KIR3DL1 alleles. PLoS One. 2014 Jun 11;9(6):e99543. PMID: 24919192; Also: http://www.google.com/patents/CA2907068A1?cl=en

Boudreau JE, Stephenson KB, Wang F, Ashkar AA, Mossman KL, Lenz LL, Rosenthal KL, Bramson JL, Lichty BD, Wan Y. IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer Res. 2011 Apr 1;71(7):2497-506PMID:21307131

Selected awards and honours

  • 2016 Dalhousie Medical Research Foundation Cameron Cancer Scientist
  • 2016 Banting Discovery Award Recipient
  • 2015 Society for Natural Immunity Abstract Award
  • 2013 American Society of Hematology Achievement Award
  • 2009 Canadian Society for Immunology – Poster award