Paola Marcato

Education

BA/BSc, University of Alberta
PhD, University of Alberta
Postdoctoral Training, Dalhousie University

Research interests

My laboratory has two main research focuses both related to breast cancer progression. First, we are trying to understand the role that cancer stem cells (CSCs) play in breast cancer metastasis. Second, we are investigating the role of the retinoic acid signaling pathway in CSC biology and breast cancer progression.

Selected publications

For a complete list of Dr. Marcato's publications, click here.

1.    Sultan M, Vidovic D, Paine AS, Huynh TT, Coyle KM, Thomas ML, Cruickshank BM, Dean CA, Clements DR, Kim Y, Lee K, Gujar SA, Weaver IC, Marcato P (2018) Epigenetic silencing of TAP1 in Aldefluor⁺ breast cancer cells contributes to their enhanced immune evasion. Stem Cells doi: 10.1002/stem.2780

2.    Coyle KM, Maxwell S, Thomas ML, Marcato P (2017) Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression. Sci. Rep. 10.1038/s41598-017-16687-6.

3.    Thomas ML, De Antueno R, Coyle KM, Sultan M, Cruickshank B, Giacomantonio M, Giacomantonio CA, Duncan R, Marcato P. (2016) Citral reduces breast tumour growth by inhibiting cancer stem cell marker ALDH1A3. Mol. Oncol.10(9):1485-1496

4.    Coyle KM, Murphy P, Vidovic D, Dean CA, Sultan M, Clements D, Wallace M, Vaghar-Kashani A, Thomas ML, Giacomantonio CA, Helyer L, Gujar S, Lee PWK, Weaver I, Marcato P. (2016) Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. Oncotarget. 7(28):44096-112.Blandino G, Pass H, Cioce MA (2015) STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations. Oncotarget. 6(14):12637-53.

5.    Marcato P*, Dean CA, Liu R-Z, Coyle KM, Bydoun M, Wallace M, Clements D, Turner C, Mathenge E, Gujar SA, Giacomantonio CA, Mackey JR, Godbout R, Lee PWK* (2015) Aldehyde dehydrogenase 1A3 influences breast cancer growth rate via differential retinoic acid signaling. Mol. Oncol. 9(1):17-31.

6.  Marcato P, Dean CA, Pan D, Araslanova R, Gillis ME, Joshi M, Helyer L, Pan L, Leidal A, Gujar S, Giacomantonio CA, Lee PWK (2011) Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells. 29(1):32-45.View additional publications on PubMed