Paola Marcato

Professor, Canadian Breast Cancer Foundation-Atlantic Region Endowed Chair in Breast Cancer Research

P Marcato August 2018

Currently recruiting graduate students and PDFs

Phone: 902-494-4239
Fax: 902-494-2519
Mailing Address: 
Department of Pathology
Dalhousie University
Sir Charles Tupper Medical Building, Room 11C1
5850 College Street
PO Box 15000
Halifax Nova Scotia Canada B3H 4R2
Research Topics:
  • Cell Biology
  • Cancer Biology
  • Breast Cancer
  • Cancer Stem Cells
  • non-coding RNA



BA/BSc, University of Alberta
PhD, University of Alberta
Postdoctoral Training, Dalhousie University

Research interests

The research projects in my laboratory have the long-term goal of developing improved therapeutic strategies for breast cancer based on a precision medicine approach. We use transcriptome and genome-wide functional assays, cell lines, patient-derived xenografts (PDXs), mouse tumor models, and analysis of published patient datasets to identify biomarkers, study breast cancer stem cells (CSCs) and understand factors important in breast cancer progression. 

Selected publications

For a complete list of Dr. Marcato's publications, click here.

  1. McLean MEMacLean MCahill HFArun RPWalker OLWasson MCDFernando WVenkatesh JMarcato P (2023) The expanding role of cancer stem cell marker ALDH1A3 in cancer and beyond, Cancers 15(2): (492)
  2. Dahn MLWalsh HRDean CAGiacomantonio MAFernando WMurphy JPWalker OLWasson MCDGujar SPinto DMMarcato P (2022) Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis. Metabolomics 18(1):9 doi: 10.1007/s11306-021-01864-6
  3. Cruickshank BM*, Wasson M-CD*Brown JMFernando WVenkatesh JWalker OLMorales-Quintanilla FDahn MLVidovic DDean CA, Van Iderstine C, Bedard K, Dellaire G, Marcato P(2021) LncRNA PART1 promotes proliferation and migration, is associated with cancer stem cells, and alters the miRNA landscape in triple-negative breast cancer. Cancers 13(11):2644. doi: 10.3390/cancers13112644    *co-first
  4. Sultan M, Nearing JT, Brown JM, Huynh TT, Cruickshank BM, Lamoureaux E, Vidovic D, Dahn ML, Fernando W, Giacomantonio CA, Langille MGI, Marcato P (2021). An in vivo genome-wide shRNA screen identifies BCL6 as a targetable paclitaxel resistance mediator in breast cancer. Mol Oncol. 15(8):2046-2064. doi: 10.1002/1878-0261.12964. 
    Featured cover article for August 2021 issue 
  5. Venkatesh JWasson M-CDBrown JMFernando WMarcato P (2021) LncRNA-miRNA axes in breast cancer: novel points of interaction for strategic attack Cancer Letters. 509:81-89. doi: 10.1016/j.canlet.2021.04.002.
  6. Vidovic DHuynh TT, Konda P, DeanCASultan MCruickshank BCoyleKM, Gujar SA, MarcatoP (2020) ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells. Cell Death Diff 27(1):363-378. doi: 10.1038/s41418-019-0362-1.