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Paola Marcato

Assistant Professor

Marcato2
Department of Microbiology & Immunology

Email: paola.marcato@dal.ca
Phone: 902-494-4239
Fax: 902-494-2519
Mailing Address: 
Department of Pathology
Dalhousie University
Sir Charles Tupper Medical Building, Room 11C1
5850 College Street
PO Box 15000
Halifax Nova Scotia Canada B3H 4R2
 
Research Topics:
  • Cell Biology
  • Cancer Biology
  • Breast Cancer
  • Cancer Stem Cells

 

Education

BA/BSc, University of Alberta
PhD, University of Alberta
Postdoctoral Training, Dalhousie University

Research interests

My laboratory has two main research focuses both related to breast cancer progression. First, we are trying to understand the role that cancer stem cells (CSCs) play in breast cancer metastasis. Second, we are investigating the role of the retinoic acid signaling pathway in CSC biology and breast cancer progression.

Selected publications

  • Marcato, P., Dean, C.A., Liu, R.-Z., Bydoun, M., Wallace, M., Clements, D., Turner, C., Mathenge, E., Gujar, S.A., Giacomantonio, C.A., Mackey J.R., Godbout, R., Lee, P.W.K. Breast cancer stem cell marker ALDH1A3 initiates retinoic acid signaling and determines breast cancer progression (submitted).
  • Marcato, P., Dean, C.A., Giacomantonio, C.A., Lee, P.W.K. (2011) Aldehyde dehydrogenase: its role as a cancer stem marker comes down to the specific isoform. Cell Cycle. 10(9):1378-84.
  • Marcato, P., Dean, C.A., Pan, D., Araslanova, R., Gillis, M.E., Joshi, M., Helyer, L., Pan, L., Leidal, A., Gujar, S., Giacomantonio, C.A., Lee, P.W.K. (2011) Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells. 29(1):32-45.
  • Marcato, P., Dean, C.A., Giacomantonio, C.A., Lee, P.W.K. (2009) Oncolytic reovirus effectively targets breast cancer stem cells. Mol. Ther. 17(6):972-9.
  • View additional publications on PubMed