Professor and Killam Chair in Virology
Dr. Duncan is not currently recruiting new students
Sir Charles Tupper Medical Building, Room 7S,
5850 College Street
PO Box 15000
Halifax Nova Scotia Canada B3H 4R2
- Cancer Biology
- Cell Biology
- Actin Cytoskeleton
- Cancer Cell Migration
- Muscle Cell Differentiation
- Cell-Cell Fusion
BSc, University of Guelph
MSc, Queen’s University
PhD, University of Guelph
Postdoctoral Training, University of Calgary
Dr. Duncan’s research group discovered the reovirus fusion-associated small transmembrane (FAST) proteins, a novel family of virus-encoded fusogens that mediate cell-cell membrane fusion. His interests are focused on biochemical and biophysical analysis of the FAST proteins, cellular pathways involved in cell-cell fusion, and factors that affect actin dynamics during membrane fusion and cell migration.
For a complete list of Dr. Roy Duncan's publications, click here.
- Parmar, H. and Duncan, R., (2016) A novel tribasic Golgi export signal directs cargo protein interaction with activated Rab11 and AP-1–dependent Golgi–plasma membrane trafficking Mol. Biol. Cell 27:1320-1331
- Read, J., Clancy, E.K., Sarker, M., de Antueno, R., Langelaan, D.N., Parmar, H.B., Shin, K., Rainey, J.K. and Duncan, R., (2015) Reovirus FAST proteins drive pore formation and syncytiogenesis using a novel helix-loop-helix fusion-inducing lipid packing sensor PLoS Pathog 11(6):e1004962
- Kai, F., Fawcett, J., and Duncan, R., (2015) Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration Oncotarget 6: 11162-11174.
- Key, T. and Duncan, R., (2014) A compact, multifunctional fusion module directs cholesterol-dependent homomultimerization and syncytiogenic efficiency of reovirus p10 FAST proteins. PLOS Pathogens 10:e1004023
- Ciechonska, M. and Duncan, R., (2014) Reovirus FAST proteins: virus-encoded cellular fusogens. Trends in Microbiology 22:715-724
- Parmar, H., Barry, C., Kai, F., and Duncan, R., (2014) Golgi complex-plasma membrane trafficking directed by an autonomous, tri-basic Golgi export signal Mol. Biol. Cell 25:866-878
- Top, D., Read, J., Dawe, S., Syvitski, R., and Duncan, R.* (2012). Cell-cell membrane fusion induced by the p15 FAST protein requires a novel fusion peptide motif containing a myristoylated polyproline type II helix. J. Biol. Chem. 287: 3403-3414.
- Top, D., Barry, C., Racine, T., Ellis, C., and Duncan, R.* (2009). Enhanced fusion pore expansion mediated by the trans-acting endodomain of the reovirus FAST proteins. PloS Pathogens 5: e1000331.
- Salsman, J., Top, D., Barry, C. and Duncan, R.* (2008). A virus-encoded cell-cell fusion machine dependent on surrogate adhesins. PloS Pathogens 4: e1000016.
- Top, D., de Antueno, R., Salsman, J., Corcoran, J., Mader, J., Hoskin, D., Jerricho, M. and Duncan, R.* (2005). Liposome reconstitution of a minimal protein-mediated membrane fusion machine. EMBO J. 24: 2980-2988.
Selected awards and honours
- Killam Chair in Virology
- University Research Professorship, Dalhousie University
- Max Forman Senior Research Prize, Dalhousie Medical Research Foundation
- Educator of the Year Award, Department of Microbiology & Immunology
- Mentor Professor, Dalhousie University
- D.G. Ingram Award for Ph.D. Thesis of the Year, Sigma XI Society
Other interests and achievements
- Founder and CEO, Fusogenix Inc.
- CIHR Institute Advisory Board, Institute of Infection and Immunity
Gardening with chainsaws