Ketan KulkarniMD

Division of Hematology-Oncology, Assistant Professor

kulkarni_profile (2)

Email: ketan.kulkarni@iwk.nshealth.ca
Phone: 902-470-3795
Fax: 902-470-7216
Mailing Address: 
Division of Hematology-Oncology
IWK Health Centre
PO Box 9700
5850-5980 University Ave.
Halifax, NS B3K 6R8
 
Research Topics:
  • Pediatric thrombosis
  • Clinical outcomes research
  • Supportive care in oncology
  • Leukemia/Lymphoma
  • Microbiome research in pediatric oncology

Education

  • Pediatric Hematology Oncology (Stollery Children’s Hospital, Edmonton, Alberta)
  • Pediatric Thrombosis (Clinical and Research Fellowship, University of Alberta, Edmonton, Alberta)

Research interests

I have been interested in studying adverse events related to cancer and its therapy, complications associated with central venous catheters, and survival outcomes. To advance research and knowledge in the same, I am actively engaged in collaboration with basic and translational researchers in pharmacy, pharmacology, gastroenterology, immunology, cancer biology, mathematics and bioinformatics, and epidemiology amongst others to find innovative ways of improving the care of pediatric hematology oncology patients. I attempt to focus on using advanced technologies to improve care and outcome of children with cancer. I am fortunate to have an expanding research program with several students and trainees at all levels of training from undergraduate to postdoctoral and well as medical students and residents. 

I am also interested in studying thrombosis in high risk pediatric populations such as oncology, cardiology, intensive care and neonatology.

Selected publications  

  1. Forbrigger, Kuhle S, Brown MM, Moorehead PC, Digout C, Kulkarni K. The association of venous thromboembolism with survival in pediatric cancer patients: A population-based cohort study. Ann Hematol. 2018;97:1903-1908. https://doi.org/10.1007/s00277-018-3371-0 (Note: Trainee as lead author. Role: Lead and senior investigator)
  2. P.-Marcotte M-C; Pole J; Kulkarni K, Athale U, Stammers D, Brandão LR, Sung L. Thrombo-embolism in children with cancer: a population-based study. Thromb Haemost.  2018;118:1646-1655. doi: 10.1055/s-0038-1668543. (Role: Co-investigator)
  3. Maclean J, MacDonald T, Digout C, Smith N, Rigby K, Kulkarni K. Need for tissue plasminogen activator for central venous catheter dysfunction is significantly associated with thrombosis in pediatric cancer patients. Pediatr Blood Cancer. 2018;65:e27015. doi:10.1002/pbc.27015. (Note: Trainee as lead author. Role: Lead and senior investigator)
  4. Truong T, Pole J, Barber R, Dix D, Kulkarni K, Martineau E, Randall A, Stammers D, Strahlendorf C, Strother D, Sung L. Enrollment on clinical trials does not improve survival for children with acute myeloid leukemia: a population-based study. Cancer. 2018124:4098-4106. doi: 10.1002/cncr.31728 (Role: Co-investigator)
  5. Kulkarni K, Muia J, Boulaftali Y, Blondon M, Lauw M. Early career professionals: a challenging road. Res Pract Thromb Hemost.2018;2:11-13. https://doi.org/10.1002/ rth2.12070 (Role: Lead author)
  6. Strahlendorf C, Pole J, Barber R, Dix D, Kulkarni K, Martineau E, Randall A, Stammers D, Strothers D, Truong T, Onysko J, Sung L. Does enrolling children with ALL on a clinical trial make a difference? A population based study. Br J Cancer. 2018; 118,744–749. Doi:10.1038/bjc.2017.462 (Role: Co-investigator)
  7. Borretta L, MacDonald N, Digout C, Smith N, Fernandez C, Kulkarni K. Management Experience of Peripherally inserted central catheters in Pediatric Oncology Patients: A 15 year Population-Based review from Maritimes, Canada. J Pediatr Hematol Oncol.2018;40:e55–e60 (Note: Trainee as lead author. Role: Lead and senior investigator)
  8. Asyyed Z, MacDonald T, Digout C, Kulkarni K. Incidence and characteristics of venous thrombotic events in pediatric cancer patients: A 20-year experience in the Maritimes, Canada. Pediatric Hematol Oncol.2017;34:90-99 (Note: Trainee as lead author. Role: Lead and senior investigator)
  9. Pole J, Barber R, Bergeron R, Caret AS, Dix D, Kulkarni K, Martineau E, Randall A, Stammers D, Strahlendorf C, Strothers D, Truong T, Sung L. Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study. BMC Cancer.2017;17:402 DOI:10.1186/s12885-017-3390-3396 (Role: Co-investigator)
  10. Kulkarni KP. The continuing evolution of technology in cancer care. Future Oncol.2016;12:1961-1965 (Role: Lead author)
  11. Kulkarni KP. Not just another “guidance document”: much more. J Thromb Hemostat. 2016.doi: 10.1111/jth.13509 (Role: Lead author)
  12. MacDonald T, Kulkarni K, Bernstein M, Fernandez CV. Allergic reactions with intravenous compared to intramuscular pegasparagase in children with high risk acute lymphoblastic leukemia: a population based study from the Maritimes, Canada. J Pediatr Hematol Oncol.2016;38:341-344 (Role: Co-lead author)
  13. Mostert S, Lam C, Njuguna F, Patenaude A, Kulkarni K, Salaverria C. Hospital Detention practices: Statement of global task force. Lancet.2015;386:649 (Role: Co-author, member of global task force on detention practices in oncology)
  14. Kulkarni KP. New frontiers of “techno-oncology” as a platform for global improvement in the outcomes of childhood cancer. Expert Rev hematol.2015;8:1-4 (Role: Lead author)
  15. Kulkarni KP, Halton J, Spavor M, Israels SJ, Abish S, Yong J, Yasui Y, Mitchell LG. Increased requirement for central venous catheter replacement in pediatric oncology patients with deep venous thrombosis: A multicentre study. Thromb Haemost.2015;113:434-435 (Role: Lead author)

Selected awards and honours

  1. International Society of Pediatric Oncology (SIOP) 2018. Best Poster Award. MacLean J, Digout C, Rigby K, MacDonald T, Kulkarni K. Age, sarcoma and use of tunneled lines are independently associated with requirement of tissue plaminogen activator for episodes of central venous catheter dysfunction. Pediatr Blood Cancer.2017;64:Supplement S3:S139
  2. Beatrice Hunter Cancer Research Institute establishment grant (2018-2020)
  3. Clinical Application of Microbiome in Pediatrics (CAMP) WAVE 2 competition: Successful nomination (2017)
  4. Nova Scotia Health research foundation establishment grant (2017-2020)
  5. International Society of Pediatric Oncology (SIOP) 2014 Young Investigator Award for the abstract “Establishing Incidence and Characteristics of Symptomatic Venous Thrombotic Events in Pediatric Cancer Patients in the Maritimes, Canada:  A population-based study"