Selected Publications

The following list of refereed publications is presented accorded to the area of research: spinal cord circuits, stem cells and clinical. The names of trainees under Dr. Rob Brownstone’s direct supervision are underlined.

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Spinal cord circuits

Bretzner F, and Brownstone RM (2013). Lhx3-Chx10 reticulospinal neurons in locomotor circuits. J. Neurosci. 33:14681–14692.
Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, and Brownstone RM. (2013). Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron 78:191-204.

Mitra P and Brownstone RM. (2012) An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse. J Neurophysiol 107: 728–741.

Stuart DG and Brownstone RM. (2011) The beginning of intracellular recording in spinal neurons: facts, reflections, and speculations. Brain Res. 1409:62-92.

Brownstone RM and Stuart DG.  (2011) Whither motoneurons?  Brain Res. 1409:93-103.

Brownstone RM, Krawitz S, and Jordan LM. (2011) Reversal of the late phase of spike frequency adaptation in cat spinal motoneurons during fictive locomotion. J Neurophysiol 105:1045-50.

Brownstone RM and Bui TV (2010) Spinal interneurons providing input to the final common path during locomotion. In Jean-Pierre Gossard, Réjean Dubuc and Arlette Kolta, editors: Progress in Brain Research, Burlington: Academic Press, Vol. 187, pp. 81-95.

Wilson JM, Blagovechtchenski E and Brownstone RM. (2010) Genetically-defined inhibitory neurons in the mouse spinal cord dorsal horn: a possible source of rhythmic inhibition of motoneurons during fictive locomotion. Journal of Neuroscience 30(3):1137–1148.

Zagoraiou L, Akay T, Martin JF, Brownstone RM, Jessell TM and Miles GB. (2009) A cluster of cholinergic pre-motor interneurons modulates locomotor activity in mouse. Neuron 64(5): 645–662.

Carlin K, Bui T, Dai Y and Brownstone RM. (2009) Staircase currents in motoneurons: Insights into asymmetry and clustering of calcium channels in the dendritic tree. Journal of Neuroscience 29: 5343-5353.

Brownstone R.M. and Wilson JM. (2008) Strategies for delineating spinal locomotor rhythm generating networks and the possible role of Hb9 interneurons in rhythmogenesis. Brain Res Rev. 57:64-76.

Al-Mosawie A, Wilson JM and Brownstone RM.  (2007) Heterogeneity of V2-derived interneurons in the adult mouse spinal cord.  European Journal of Neuroscience, 26:3003–3015.

Wilson, JM, Cowan A and Brownstone RM.  (2007) Heterogeneous electrotonic coupling and synchronization of rhythmic bursting activity in mouse Hb9 interneurons.  Journal of Neurophysiology 98: 2370–2381.

Wilson J.M., Dombeck D.A., Diaz-Rios M, Harris-Warrick R.M., and Brownstone R.M. (2007) Two-photon calcium imaging of network activity in XFP expressing neurons in the mouse.  Journal of Neurophysiology; 97:3118-25.

Miles G., Hartley R., Todd A.J. and Brownstone R.M. (2007) Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion.  Proceedings of the National Academy of Sciences USA 104:2448-53.

Brownstone R.M. (2006). Beginning at the end: Repetitive firing properties in the final common pathway. Progress in Neurobiology. 78:156-72.

Wilson J.M., Hartley R., Maxwell D.J., Todd A.J., Lieberam I., Kaltschmidt J.A., Yoshida Y., Jessell T.M., and Brownstone R.M. (2005) Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein. Journal of Neuroscience 25:5710-5719.

Miles G.B., Dai Y., and Brownstone R.M. (2005) Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones. Journal of Physiology (London) 566:519-32.

Wilson J.M., Rempel J., Brownstone R.M. (2004) Post-natal development of cholinergic synapses on mouse spinal motoneurones. Journal of Comparative Neurology 474:13-23.

Heckman C.J., Lee R.H., and Brownstone R.M.  (2003) Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior.  Trends in Neurosciences. 26: pp. 688-695.

Carlin K., Jones K.E., Jiang Z., Jordan L.M. and Brownstone R.M. (2000) Dendritic L-type calcium currents in mouse spinal motoneurones: implications for bistability. Eur. J. Neurosci. 12:1635-1646.

Carlin K., Jiang Z., and Brownstone R.M. (2000) Characterisation of calcium currents in functionally mature mouse spinal motoneurones. Eur. J. Neurosci. 12:1624-1634

Stem cell research

Bretzner F, Gilbert F, Baylis F, and Brownstone RM.  (2011) Target populations for first-in-human embryonic stem cell research in spinal cord injury. Cell Stem Cell 8:468-73.

Yohn DC, Miles GB, Rafuse VF, and Brownstone R M. (2008) Transplanted mouse embryonic stem cell-derived motoneurons form functional motor units and reduce muscle atrophy. Journal of Neuroscience 28(47):12409 –12418.

Soundararajan P., Miles G.B., Rubin L.L., Brownstone R.M., and Rafuse V.M. (2006) Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. Journal of Neuroscience 26:3256-68.

Miles G.B., Yohn D.C., Wichterle H, Jessell T.M., Rafuse V.F., Brownstone R.M. (2004). Functional properties of motoneurons derived from mouse embryonic stem cells. Journal of Neuroscience 24: 7848-7858.