Department of Pathology

Dalhousie University

Kathryn McFadden, MD

Associate Professor

PATH-BioDefault-500-Black-NoShield
Department of Pathology

Email: Kathryn.McFadden@IWK.nshealth.ca
Research Topics:
  • Brain anatomy, development and malformations
  • Pediatric brain tumors
  • Neuropathology and genetics of neuropsychiatric disorders
  • Telepathology
  • Congenital cystic lung lesions
  • Genetic musculoskeletal disorders
  • Skeletal biology and paleopathology
  • History of Medicine
Specific Expertise
  • Immunohistochemical analysis including antibody validation and troubleshooting
  • Tissue banking
  • Fetal and post-natal human, non-human primate, rodent, and chick CNS anatomy, dissection and stereotactic histologic analysis
  • Light microscopy
  • Digital microscopy
  • Stimulated Raman scattering (SRS) microscopy

Biography

Dr. Kate McFadden is a pediatric pathologist and neuropathologist who diagnoses and investigates diseases, including tumors, that occur during fetal development, infancy, childhood, and adolescence. She is interested in brain development and malformations, pediatric brain tumors, telepathology, congenital cystic lung lesions, and history of medicine.

Education

  • BA:  Social Anthropology, Dalhousie University
  • BSc: Physical Anthropology, University of Toronto
  • MA: Physical Anthropology, University of Toronto
  • MD: University of Pittsburgh
  • Residency: Anatomic Pathology, University of Pittsburgh
  • Fellowship: Neuropathology, University of Pittsburgh
  • Fellowship: Pediatric Pathology, University of Pittsburgh

Selected Publications

  • Howie C, Ahmad T, McFadden K, Crooks B, McNeely PD, Walling S, Rutledge R, Sahm F, Jabado N, Kieran M, Erker C. Diagnostics and prospective outcome of a diffuse glioneuronal tumor with oligodendroglioma like features and nuclear clusters after surgical resection (DGONC): a case report. NeuroOncology Advances. 2022; 4:1–5.
  • Boivin M, Deng J, Pfister V, Grandgirard E, Oulad-Abdelghani M, Ruffenach F, Negroni L, Koebel P, Jacob H, Riet F, Dijkstra AA, McFadden K, Wiley CA, Sone J, Wang Z, Berguerand NC. Translation of expanded GGC repeats in a toxic polyglycine-containing protein in NIID defines a novel class of human genetic disorders: the polyG diseases. Neuron. 2021 Jun 2;109(11):1825-1835.
  • Zureick AH, Marini BL, McFadden KA, Robertson PL, Mody R, Koschmann CJ.  Successful treatment of a TSC2-mutant glioblastoma with everolimus. BMJ Case Reports 2019 May 31;12(5).
  • Koschmann C, Wu Y-M, Kumar-Sinha C, Lonigro R, Vats P, Kasaian K, Cieslik M, Cao X, Frank K, Prensner J, Zureick A, Everett J, Bailey Anderson B, Marini B, Camelo-Piragua S, Venneti S, McKeever P, McFadden K, Lieberman L, Leonard M, Maher C, Garton H, Muraszko K, Robertson P, Robinson D, Chinnaiyan A,  Mody R. Clinically integrated sequencing demonstrates utility in children and young adults with high-risk glial brain tumor tumors. JCO Precision Oncology.  2018 May 4.
  • Pratt D, Camelo-Piragua S, McFadden K, Leung D, Mody R, Chinnaiyan A,  Koschmann C, Venneti S. Novel BRAF-β3-αC loop activating mutations in V600E-negative anaplastic pleomorphic xanthroastrocytoma. Acta Neuropathologica Communications Neuroscience of Disease 2018 6:24.
  • Orringer DA, Pandian B, Niknafs YS, Hollon TC, Boyle J, Lewis S, Garrard M, Hervey-Jumper SL, Garton HJL, Maher CO, Heth JA, Sagher O, D. Wilkinson DA, Snuderl M, Venneti S, Ramkissoon SH, McFadden KA, Fisher-Hubbard A, Lieberman AP, Johnson TD, X. Xie XS, Trautman JK, Freudiger CW, Camelo-Piragua S. Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy. Nat Biomed Eng. 2017;1.
  • Hollon T, Lewis S, Pandian B, Niknafs Y, Garrard M, Garton H, Maher C, McFadden K, Snuderl M, Lieberman A, Muraszko K, Camelo-Piragua S, Orringer D. Rapid intraoperative diagnosis of pediatric brain tumors using stimulated raman histology. Cancer Res. 2017 Nov 1.
  • Qaddoumi I, Orisme W, Wen J, Santiago T, Gupta K, Dalton JD, Tang B, Haupfear K, Punchihewa C, Easton J, Mulder H, Boggs K, Shao Y, Rusch M, Becksfort J, Gupta P, Wang S, Lee RP, Brat D, Peter Collins V, Dahiya S, George D, Konomos W, Kurian KM, McFadden K, Serafini LN, Nickols H, Perry A, Shurtleff S, Gajjar A, Boop FA, Klimo PD Jr, Mardis ER, Wilson RK, Baker SJ, Zhang J, Wu G, Downing JR, Tatevossian RG, Ellison DW. Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol. 2016 Jun;131(6): 833-45.
  • McFadden K, Minshew NJ: Evidence for dysregulation of axonal growth and guidance in the etiology of ASD. Front Hum Neurosci. 2013 Oct 22;7:671.
  • Melhem N, Middleton F, McFadden K, Klei L, Faraone SV, Vinogradov S, Tiobech J, Yano V, Kuartei S, Roeder K, Byerley W, Devlin B, Myles-Worsley M: Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees. Biol Psychiatry. 2011 Dec 15;70(12):1115-21.