Department of Pathology

Dalhousie University

Manal Elnenaei, MBChB, PhD, FRCPath

Professor

PATH-ElnenaeiManal-2026-08
Department of Pathology

Email: manal.elnenaei@nshealth.ca
Phone: 902-473-5194
Fax: 902-473- 2123
Mailing Address: 
Room 616 Mackenzie Building
5788 University Avenue
Halifax, NS, B3H 1V8
 
Research Topics:
  • Multiple Myeloma
  • Myeloma Tumour Bank
  • Endocrine clinical research
  • Health informatics

This supervisor is not able to supervise new trainees at this time. If you are searching for a supervisor, please contact pathgrad@dal.ca.

Head of Clinical Chemistry, Department of Pathology

Biography

Dr. Manal Elnenaei has created and is leading the Myeloma Tumor Bank initiative. This project has brought together a multidisciplinary team comprising Dalhousie Faculty as well Clinician Scientists, to focus on translational research in Multiple Myeloma. Objectives of this research include a joint focus on clinical genetics and immunology for patients with MM and leveraging our unique, multidisciplinary expertise to create faithful models of cancer, establish and test new treatment modalities towards precision medicine.

Dr. Elnenaei is working closely with the endocrine team on clinical research projects that involve laboratory testing for endocrine patients and local guidelines that enhance clinical value in laboratory testing.

Appropriate test utilization is a strong area of interest for Dr. Elnenaei and is part of the NSHA Choosing Wisely group. A number of initiatives in this area have produced substantial savings by reducing the number of unnecessary tests produced by the laboratory. She is also working closely with the Dalhousie Health Informatics team on initiatives that have a broader stakeholder impact.

Education & Professional Designations

  • European Specialist in Laboratory Medicine (EuSpLM), 2012.
  • Certificate of Completion of Training (CCST), General Medical Council, UK, 2010.
  • Fellowship of the Royal College of Pathologists, UK (FRCPath), 2010.
  • PhD in Pathology, University of London (Topic: Genetic Characterization of Multiple Myeloma), 2002.
  • Masters in Clinical and Chemical Pathology, Faculty of Medicine, University of Alexandria, Egypt, 1995.
  • Bachelor of Medicine and Surgery (MBChB), with Distinction, Faculty of Medicine, University of Alexandria, Egypt, 1989.

Teaching

  • Regular instructor/ teacher on the Bioc4813/5813Path5013 course on ‘Biochemistry of Clinical Disoders’
  • Resident teaching and mentoring: mainly General Pathology residents; but also includes Endocrine and Hematopathology residents.
  • Supervision of summer students and MSc students, when time and resources permit.
  • Medial school tutoring in Metabolism I and Metabolism II units.
  • Accepting observership placements, when time and resources permit.
  • Regular participation in local staff and Faculty teaching via Grand Rounds, Lunch and Learn and Journal Club activities.

Selected Publications

  1. Lou A, Elnenaei M, Liu E, McLeod M, Francheville J, Mahida S, Awara Y, and Zhu J. Evaluation of a novel albumin platelet product (APP) fibrosis index and three non-invasive fibrosis indices in metabolic dysfunction–associated steatotic liver disease. Canadian Liver Journal 2025 August; 8(3): 472-483. doi.org/10.3138/canlivj-2025-0017
  2. Elnenaei MO, Thoni A, Mattman A. Degrowth in the clinical laboratory: A key step towards integrating planetary health into the healthcare system. Clin Biochem. 2025 Oct 14:111029. doi: 10.1016/j.clinbiochem.2025.111029. Epub ahead of print. PMID: 41101615.
  3. Cutler S, Trottier AM, Liwski R, Quinn J, Gaston D, Veinotte R, Pierre JS, White D, Forward N, De La Torre A, Elnenaei M. Novel proteomic characterization of multiple myeloma bone marrow interstitial fluid links prognosis to coagulation pathways. Clin Proteomics. 2025 Oct 21;22(1):40. doi: 10.1186/s12014-025-09560-6. PMID: 41120896; PMCID: PMC12542439.
  4. Beriault DR, Chen Y, Yip P, Blasutig I, Bhayana V, Rutledge AC, Parker M, Kinniburgh D, Thomas D, Colbourne P, Langman L, Delaney SR, Bennett M, Oleschuk C, Huang Y, Rodriguez-Capote K, Hauff K, Konforte D, Kalra J, Bouhtiauy I, El Hassan MA, Elnenaei M, Thorlacius L, Venner AA, Randell EW, Sohn KY, Leung F, Taher J, Lou A, Arnoldo S; CSCC Utilization Special Interest Group. Choosing Wisely Canada recommendations for clinical biochemistry: test ordering for sustainable and high-quality patient care. Clin Biochem. 2025 Aug;138:110951. doi: 10.1016/j.clinbiochem.2025.110951. Epub 2025 May 21. PMID: 40409393.
  5. Terry Fox Research Institute Marathon of Hope Cancer Centers Network. Electronic address: mmarra@bcgsc.ca; Terry Fox Research Institute Marathon of Hope Cancer Centers Network. The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative. Cancer Cell. 2025 Apr 14;43(4):587-592. doi: 10.1016/j.ccell.2025.03.014. Epub 2025 Apr 3. PMID: 40185094.
  6. Lou A, Elnenaei MO, Zhu J, Peltekian K, Liu E, Jamieson JA, Said H, Nassar BA. Re-evaluating the utility of iron indices in hereditary hemochromatosis genotyping: A retrospective study. Clin Biochem. 2024 Nov 29:110860. doi: 10.1016/j.clinbiochem.2024.110860. Epub ahead of print. PMID: 39617311.
  7. ElMenshawy N, Ibrahim Fouda M, Mofreh M, Hisham El-Etriby H,  Elnenaei M, Eissa M. Impact of CD34/CD309 expression in circulating endothelial progenitor cells on prognosis and response to bortezomib therapy in multiple myeloma. J Immunoassay Immunochem. 2024 Sep 2;45(5):481-491. doi: 10.1080/15321819.2024.2388614. Epub 2024 Aug 13. PMID: 39135454.
  8. Lou A, Thoni A, Shandi N, Yang Z, Nassar BA, Elnenaei M. Effective stewardship strategies to enhance appropriateness of refer-out test requests in a Canadian tertiary centre laboratory. Clin Biochem. 2024 Jul;129:110777. doi: 10.1016/j.clinbiochem.2024.110777. Epub 2024 Jun 8. PMID: 38857837.
  9. Awara MA, Downing LM, Elnenaei MO. Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature. J Med Case Rep. 2023 Jan 30;17(1):40. doi: 10.1186/s13256-022-03694-z. PMID: 36717929; PMCID: PMC9885629.
  10. Awara M, Green JT, Elnenaei M. The psychiatric and neurological interface of multiple sclerosis: case report and literature review EJMCR. 2023;7(1):13-18. DOI: https://doi.org/10.24911/ejmcr/173-1651693131
  11. Beriault RD, Rodriguez-Capote K, Hauff K, Kinninburgh D, Langman L, Mattman A, Konforte D, Olechuk C, Beach L, Chen Y, Elnenaei M, Parker M, Leung F, Arnoldo S, Knauer M, Kalra J, Bouhtiauy I, Abou El Hassan M, Bailey D, Catomeris P and Simons J.  Reduce, Reuse, Recycle: Top 10 Choosing Wisely Canada’s Recommendations for Conserving Laboratory Resources.  Canadian J. of Gen Int. Med.  2022 Reduce, Reuse, Recycle: Top 10 Choosing Wisely Canada’s Recommendations for Conserving Laboratory Resources. CJIM 2022 17;4: 86-95. DOI: https://doi.org/10.22374/cjgim.v17i4.650
  12. Elnenaei MO, Thoni A, Eissa M. Reflex and reflective laboratory interventions for adding value to test results; an integral part of laboratory stewardship. Clin Biochem. 2022 Jul-Aug;105-106:16-22. doi: 10.1016/j.clinbiochem.2022.03.003. Epub 2022 Mar 18. PMID: 35314140.
  13. Mackley MP, Morgenthau A, Elnenaei M, MacKenzie H. A Rare Hemoglobin Variant (β51Pro → His) Causing Misleading Measurements of Hemoglobin A1c. J Endocr Soc. 2022 Feb 24;6(4):bvab186. doi: 10.1210/jendso/bvab186. PMID: 35237735; PMCID: PMC8884119.
  14. Kennedy BE, Giacomantonio M, Murphy JP, Cutler S, Sadek M, Konda P, Paulo JA, Pathak GP, Renkens SHJ, Grieve S, Pol J, Gygi SP, Richardson C, Gaston D, Reiman A, Kroemer G, Elnenaei MO, Gujar SA. NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma. Mol Ther Oncolytics. 2022 Feb 20;24:695-706. doi: 10.1016/j.omto.2022.02.017. PMID: 35284625; PMCID: PMC8904403.
  15. Cutler SD, Knopf P, Campbell CJ, Thoni A, El Hassan MA, Forward N, White D, Wagner J, Goudie M, Boudreau JE, Kennedy BE, Gujar S, Gaston D, Elnenaei MO. DMG26: A Targeted Sequencing Panel for Mutation Profiling to Address Gaps in the Prognostication of Multiple Myeloma. J Mol Diagn. 2021 Sep 22:S1525-1578(21)00290-7. doi: 10.1016/j.jmoldx.2021.08.011. Epub ahead of print. PMID: 34562616.
  16. Van Woensel W, Elnenaei M, Abidi SSR, Clarke DB, Imran SA. Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders. Clin Biochem. 2021 Aug 23:S0009-9120(21)00226-5. doi: 10.1016/j.clinbiochem.2021.08.005. Online ahead of print.
  17. Yorke JA, Lou A, Elnenaei MO, Sadeghi-Aval P, Thoni A, Nassar BA, et al. Clinical Challenges of Transitioning to High Sensitivity Thyroglobulin Assay. Annals Thyroid Res. 2021; 7(2): 329-332
  18. Elnenaei MO, Knopf P, Cutler SD, Sinclair K, Abou El Hassan M, Greer W, Goudie M, Wagner J, White D , Couban S, Forward N , Gaston D, Campbell CVJ. Low-Depth Sequencing for Copy Number Abnormalities in Multiple Myeloma Supersedes Fluorescent in Situ Hybridization in Scope and Resolution. Clin Genetics. 2019 96(2):163-168. doi: 10.1111/cge.13561
  19. Awara MA, Smalley JG, Havenga M, Elnenaei MO. Trials and Tribulations of Diagnosing and Managing Psychosis Secondary to Non-Convulsive Epilepsy.  EJMCR 2020 4(1):19–24. doi.org/10.24911/ejmcr/173-1558018778
  20. Kennedy BE, Sadek M, Elnenaei MO, Reiman A, Gujar SA. Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma. Trends Cancer. 2020; 6(1):9-12. doi: 10.1016/j.trecan.2019.11.005.
  21. Campbell SG, Innes GD, Magee KD, Elnenaei MO, Rowe BH. A 5-step program for diagnostic test addiction. CJEM 2019 May 16:1-4. doi: 10.1017/cem.2019.350.
  22. Abidi SR , Rad J , Abusharekh A , Roy P, Van Woensel W , Cheng C , Abidi SR, Crocker B, Elnenaei M. AI-Driven Pathology Laboratory Utilization Management via Data- and Knowledge-Based Analytics.  In: Riaño D., Wilk S., ten Teije A. (eds) Artificial Intelligence in Medicine. AIME 2019. Lecture Notes in Computer Science, vol 11526. Springer, Cham. doi.org/10.1007/978-3-030-21642-9_30
  23. Abou El Hassan M, Delvin E, Elnenaei MO, Hoffman B.  Diurnal rhythm in clinical chemistry: An underrated source of variation, Critical Reviews in Clinical Laboratory Sciences. 2018; 55:8, 516-534, DOI: 10.1080/10408363.2018.1519522.
  24. Elnenaei MO, Minney D, Clarke DB, Kumar-Misir A, Imran SA. Reflex and reflective testing strategies for early detection of pituitary dysfunction. Clin Biochem. 2018; 54:78-84
  25. Munro V, Elnenaei MO, Doucette S, Clarke DB, Imran SA. The effect of time of day testing and utility of 30 and 60 minute cortisol values in the 250 mcg ACTH stimulation test. Clin Biochem. 2018; 54:37-41
  26. Lou AH, Elnenaei MO, Sadek I, Thompson S, Crocker BD, Nassar BA. Multiple pre- and post-analytical lean approaches to the improvement of the laboratory turnaround time in a large core laboratory. Clin Biochem. S0009-9120(17)30328-4.
  27. Elnenaei MO , Campbell SG , Thoni AJ,  Lou A , Crocker BD, Nassar BA An effective utilization management strategy by dual approach of influencing physician ordering and gate keeping. Clin Biochem. 2016;49:208-12.