Conrad FernandezMD

Division Head Pediatric Hematology/Oncology, Professor

Fernandez_profile

Email: conrad.fernandez@iwk.nshealth.ca
Phone: 902-470-6839
Mailing Address: 
Division of Hematology-Oncology
Room K7122, 7th Floor
IWK Health Centre
PO Box 9700
5850-5980 University Ave.
Halifax, NS B3K 6R8
 
Research Topics:
  • Wilms tumor
  • Research ethics
  • Return of genomic results

Education

  • Hon BSc, Genetics (University of Western Ontario)
  • MD (McMaster University)
  • FRCPC Pediatrics (Dalhousie University)
  • Specialist Certificate Pediatric Hematology/Oncology (University of British Columbia)

Research interests

Dr. Fernandez chair of the international Children’s Oncology Group Renal Tumors Steering Committee and conducts clinical trials in childhood kidney cancer. He also has an active research program in returning research results to participants.

Selected publications

  • Mullen EA, Chi YY, Hibbits E, Anderson JR, Steacy KJ, Geller JI, Green DM, Khanna G,  Malogolowkin MH,  Grundy PE, Fernandez CV and Dome JS. Impact of surveillance imaging modality on survival after recurrence in patients with Wilms tumor: A Report from the Children’s Oncology Group. J Clin Oncol. 2018 Oct 18. doi: 10.1200/JCO.18.00076. [Epub ahead of print] PMID:30335557.
  • Iaboni DSM,  Chi YY, Dome JS, Fernandez CV. Outcome of Wilms Tumor patients with bone metastasis enrolled on National Wilms Tumor Studies 1-5: A report from the Children’s Oncology Group.  Pediatric Blood Cancer.  Pediatr Blood Cancer. 2019 Jan;66(1):e27430. doi: 10.1002/pbc.27430. Epub 2018 Aug 30. PMID:30160355.
  • Cajaiba MM. Dyer , Geller JI, Jennings LJ, George D, Kirschmann D, Rohan SM, Cost N,  Khanna G, Mullen EA, Dome JS, Fernandez CV,  Perlman EJ. The Classification of Pediatric and Young Adult Renal Cell Carcinomas Registered on the Children’s Oncology Group (COG) Protocol AREN03B2 Following Focused Genetic Testing. Cancer. 2018 Aug;124(16):3381-3389. doi: 10.1002/cncr.31578. Epub 2018 Jun 15. PMID:29905933
  • Friedman JM, Bombard Y, Cornel M, Fernandez CV, Junker AK, Plon SE, Stark Z, and  Knoppers BM for the Paediatric Task Team of the Global Alliance for Genomics and Health Regulatory and Ethics Works  team.  Genome-wide Sequencing in Acutely-Ill Infants: Genome Medicine’s Critical Applicaiton? Genetics in Medicine. 2018 Jun 12. doi: 10.1038/s41436-018-0055-z. [Epub ahead of print] PMID:29895853.
  • Dix DB, Seibel NL, Chi YY, Khanna G, Gratias E, Anderson JR, Mullen EA, Geller JI, Kalapurakal JA,  Paulino AC, Perlman EJ, Ehrlich PF, Malogolowkin M, Gastier-Foster JM, Grundy PE, Fernandez CV, Dome JS on behalf of the AREN0533 Study Committee. Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children's Oncology Group AREN0533 Study.  J Clin Oncol. 2018 Jun 1;36(16):1564-1570. doi: 10.1200/JCO.2017.77.1931. Epub 2018 Apr 16.PMID:29659330.
  • Wolf SM, Scholtes E, Koenig BA, Petersen GM, Berry SA, Beskow LM, Daly MB,  Fernandez CV, Green RC, LeRoy BS, Lindor NM, O’Rourke PP, Radecki Breitkopf C, Rothstein MA, Van Ness B, and Wilfond BS.  Pragmatic Tools for Sharing Genomic Research Results with the Relatives of Living and Deceased Research Participants. J Law Med Ethics. 2018 Mar;46(1):87-109. doi: 10.1177/1073110518766024. Epub 2018 Mar 27. PMID: 30008546
  • V Rahimzadeh, C Schickhardt, BM Knoppers, K Sénécal, DF Vears, CV Fernandez, S Pfister, S Plon, EW Clayton, S Terry, J Williams, MS Williams, M Cornel, JM Friedman.  Key Implications of Data Sharing in Pediatric Genomics: Points to Consider for KIDS. JAMA Pediatrics. 2018 May 1;172(5):476-481. doi: 10.1001/jamapediatrics.2017.5500. PMID: 29554172
  • Fernandez CV,  Mullen EA, Chi YY, Ehrlich PF,  Perlman EJ, Kalapurakal JA, Khanna G, Paulino AC, Hamilton TE, Gow KW, Tochner Z,  Hoffer F, Withycombe J, Shamberger RC, Kim Y, Geller JI, Anderson JR, Grundy PE, Dome JS.  Outcome and prognostic factors in stage III Favorable Histology Wilms Tumor (FHWT).  A report from the Children’s Oncology Group Study AREN0532.  J Clin Oncol. 2018 Jan 20;36(3):254-261. doi: 10.1200/JCO.2017.73.7999. Epub 2017 Dec 6.PMID: 29211618.
  • Fernandez CV, EJ Perlman, EA Mullen, YY Chi, TE Hamilton, KW Gow, FA Ferrer, D Barnhart, PF Ehrlich,  G Khanna,  J Kalapurakal, T Bocking, V Huff, Q An, JI Geller, PE Grundy JR Anderson, JS Dome, RC Shamberger for the AREN0532 committee. Clinical outcome and biological predictors of relapse following nephrectomy only for Very Low Risk Wilms tumor (VLR WT). A report from Children’s Oncology Group AREN0532.                 Annals of Surgery. 2017 Apr;265(4):835-840. [Epub ahead of print 2016. Mar 16.]PMID:27811504. 
  • Knoppers BM, Sénécal K, Boisjoli J, Borry P, Cornel M, Fernandez CV, Grewal J, Holm IA, Nelson E, Pinxten W, Shabani M, Tassé AM, Zawati M, Clayton EW on behalf of the P3G International Paediatric Research Platform. Attaining Majority in Biomedical Research: Re-contact for Consent? IRB: Ethics & Human Research. IRB vol. 39, no. 6 November - December 2016.
  • Fernandez CV, EJ Perlman, EA Mullen, YY Chi, TE Hamilton, KW Gow, FA Ferrer, D Barnhart, PF Ehrlich,  G Khanna,  J Kalapurakal, T Bocking, V Huff, Q An, JI Geller, PE Grundy JR Anderson, JS Dome, RC Shamberger for the AREN0532 committee. Clinical outcome and biological predictors of relapse following nephrectomy only for Very Low Risk Wilms tumor (VLR WT). A report from Children’s Oncology Group AREN0532.  Annals of Surgery. 2017 Apr;265(4):835-840.
  • Sénécal K, Rahimzadeh V, Knoppers BM, Fernandez CV, Avard D, Sinnett D. Statement of Principles on the Return of Research Results and Incidental Findings in Paediatric Research: A Multi-site Consultative Process. Genome. 2015 Dec;58(12):541-8.
  • Fernandez CV,  O’Connell C, Ferguson M, Orr AC, Robitaille JM, Knoppers BM, McMaster CR. Stability of Attitudes to the Ethical Issues Raised in the Return of Incidental Genomic Research Findings in Children – A Follow up Study.  Public Health Genomics. 2015 Sept 2015;18(5):299-308.

Selected awards and honours  

  • Nominated: 2011 IWK Health Centre Family Leadership Council’s Annual Award for Excellence in Patient and Family Centred Care, Halifax, Nova Scotia, Canada.
  • Department of Pediatrics Endowment Award 2010, Canadian research committee strategies assessment, Halifax, Nova Scotia, Canada.
  • Best poster 2008, Society of International Pediatrics Annual meeting, Other Section (Ethics), Berlin, Germany.
  • Distinguished Service Award 2005, Dalhousie Health Sciences Research Ethics Board, Dalhousie University, Halifax, Nova Scotia, Canada.

Memberships

  • Children’s Oncology Group
  • American Society of Clinical Oncology
  • American Society of Pediatric Hematology/Oncology
  • American Society of Hematology
  • International Society of Pediatric Oncology (SIOP)

Employment

  • 2011 (09) - Head, Division of Pediatric Hematology/Oncology, Department of Pediatrics, IWK Health Centre, Halifax, NS.

Selected service & activity

  • 2019: Beatrice Hunter Cancer Research Institute. Research Committee. Chairperson.
  • 2018: Department of Pediatrics. Division Heads Council. Chairperson
  • 2017: Panel on Research Ethics. Secretariat on Responsible Conduct of Research. TriCouncil Policy of Canada. Member.
  • 2016: Program of Care for Cancer (Nova Scotia). Quality Improvement and Safety Council Committee and the Health Services Planning – Steering Committee. Member.
  • 2016: Renal Tumor Steering Committee, Children's Oncology Group, Chair.
  • 2016: Specialty Committee in Adolescents and Young Adults Oncology (AYA). Royal College of Physicians and Surgeons. Member.
  • 2016: Atlantic Provinces Pediatric Hematology Oncology Network. Board member.
  • 2015: PROFYLE. Terry Fox Research Institute national program to sequence high risk pediatric cancer patients.  Ethics Node chair, Steering committee member, Site lead.