» Go to news main
No difference in cerebral perfusion between the wild‑type and the 5XFAD mouse model of Alzheimer’s disease
Congratulations to Dr. Tân-Trào Phi, Dr. Chris V. Bowen, and Dr. Steven Burrell on their latest published article!
No difference in cerebral perfusion between the wild-type and the 5XFAD mouse model of Alzheimer's disease
Drew R. DeBay, Tân-Trào Phi, Chris V. Bowen, Steven C. Burrell & Sultan Darvesh
Scientific Reports volume 12, Article number: 22174 (2022)
Abstract
Neuroimaging with [2,2-dimethyl-3-[(2R,3E)-3-oxidoiminobutan-2-yl]azanidylpropyl]-[(2R,3E)-3-hydroxyiminobutan-2-yl]azanide;oxo(99Tc)technetium-99(3+) ([99mTc]HMPAO) single photon emission computed tomography (SPECT) is used in Alzheimer’s disease (AD) to evaluate regional cerebral blood flow (rCBF). Hypoperfusion in select temporoparietal regions has been observed in human AD. However, it is unknown whether AD hypoperfusion signatures are also present in the 5XFAD mouse model. The current study was undertaken to compare baseline brain perfusion between 5XFAD and wild-type (WT) mice using [99mTc]HMPAO SPECT and determine whether hypoperfusion is recapitulated in 5XFAD mice. 5XFAD and WT mice underwent a 45 min SPECT scan, 20 min after [99mTc]HMPAO administration. Whole brain and regional standardized uptake values (SUV) and regional relative standardized uptake values (SUVR) with whole brain reference were compared between groups. Brain perfusion was similar between WT and 5XFAD brains. Whole brain [99mTc]HMPAO retention revealed no significant difference in SUV (5XFAD, 0.372 ± 0.762; WT, 0.640 ± 0.955; p = 0.536). Similarly, regional analysis revealed no significant differences in [99mTc]HMPAO metrics between groups (SUV: 0.357 ≤ p ≤ 0.640; SUVR: 0.595 ≤ p ≤ 0.936). These results suggest apparent discrepancies in rCBF between human AD and the 5XFAD model. Establishing baseline perfusion patterns in 5XFAD mice is essential to inform pre-clinical diagnostic and therapeutic drug discovery programs.
Recent News
- Dr. Siân Iles interviewed on CBC's Information Morning
- Dr. Steven Beyea and Dr. Adela Cora featured in the latest Beyond Research podcast from ResearchNS
- Dr. Andreu Costa recognized as a CARJ 2023 Outstanding Reviewer!
- Department Faculty awarded EJNMMI Physics Best Paper 2023
- Dr. Hodgson wins world entrepreneurship contest
- Congratulations to the 2023 David Fraser Radiology Research Foundation Summer Studentship recipients!
- Congratulations, Dr. Brewer! The Charles Lo Prize in Radiology Research
- Radiology Research Day
Comments
comments powered by Disqus