News» Go to news main
Post‑administration dosimetry in yttrium‑90 radioembolization through micro‑CT imaging of radiopaque microspheres in a porcine renal model
The purpose of this study is to perform post-administration dosimetry in Yttrium-90 radioembolization through micro-CT imaging of radiopaque microsphere distributions in a porcine renal model and explore the impact of spatial resolution of an imaging system on the extraction of specific dose metrics.
Following the administration of radiopaque microspheres to the kidney of a hybrid farm pig, the kidney was explanted and imaged with micro-CT. To produce an activity distribution, 400 MBq of Yttrium-90 activity was distributed throughout segmented voxels of the embolized vasculature based on an established linear relationship between microsphere concentration and micro-CT voxel number.
This distribution was down-sampled to coarser isotropic grids ranging in voxel size from 2.5 to 15 mm to emulate nominal resolutions comparable to those found in Yttrium-90 PET and Bremsstrahlung SPECT imaging. Dose distributions were calculated through the convolution of activity distributions with dose-voxel kernels generated using the GATE Monte Carlo toolkit. Contours were computed to represent normal tissue and target volumes.
Dose-volume histograms, dose metrics, and dose profiles were compared to a ground truth dose distribution computed with GATE. The mean dose to the target for all studied voxel sizes was found to be within 5.7% of the ground truth mean dose. D70 was shown to be strongly correlated with image voxel size of the dose distribution (r2 = 0.90). D70 is cited in the literature as an important dose metric and its dependence on voxel size suggests higher resolution dose distributions may provide new perspectives on dose-response relationships in Yttrium-90 radioembolization.
This study demonstrates that dose distributions with large voxels incorrectly homogenize the dose by attributing escalated doses to normal tissues and reduced doses in high-dose target regions. High-resolution micro-CT imaging of radiopaque microsphere distributions can provide increased confidence in characterizing the absorbed dose heterogeneity in Yttrium-90 radioembolization.
- Just published! Surgical or Endovascular Treatment of MCA Aneurysms: An Agreement Study
- Just published! Endovascular thrombectomy and intravenous alteplase in patients with acute ischemic stroke due to large vessel occlusion: A clinical practice guideline
- Just published! Preparedness of Residents and Medical Students for the Transition to Competence by Design in Diagnostic Radiology Post‑Graduate Medical Education
- Just published! Systematic Review of Diffuse Hemispheric Glioma, H3 G34‑mutant: Outcomes and Associated Clinical Factors
- Just published! Inaugural Pan‑Canadian RADGames: Results From a Successful Approach to Radiology Education for Medical Students
- Just published! Canadian Association of Radiologists Prostate MRI White Paper
- Publication: Screening Criteria Evaluation for Expansion in Pulmonary Neoplasias (SCREEN)
- Publication: MR Imaging of Pediatric Low‑Grade Gliomas: Pretherapeutic Differentiation of BRAF V600E Mutation, BRAF Fusion, and Wild‑Type Tumors in Patients without Neurofibromatosis‑1
comments powered by Disqus