Dal Alert!

Receive alerts from Dalhousie by text message.

X

T. Alexander Quinn

Assistant Professor

Physiology_Quinn

Related information

Department of Physiology and Biophysics , School of Biomedical Engineering

Email: alex.quinn@dal.ca
Phone: 902-494-4349
Mailing Address: 
Room 3F, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Cardiovascular physiology
  • Cardiovascular disease
  • Electrophysiology
  • Mechanics
  • Mechano-electric coupling
  • Arrhythmias
  • Device-based therapies
  • Myocardial ischemia

Education

  • BSc (McGill University)
  • MSc (Columbia University)
  • PhD (Columbia University)
  • PDF (University of Oxford)
  • PDF (Imperial College London)

Research interests

Dr. Quinn’s research focuses on feedback between cardiac mechanics and electrophysiology. The goals of his research program are to investigate mechano-sensitive mechanisms at the organ, tissue, cell, and subcellular levels; discover their relevance for heart rhythm in health and disease; and use this knowledge to develop novel targeted anti-arrhythmic therapies.

Selected publications

  • Quinn TA. The importance of non-uniformities in mechano-electric coupling for ventricular arrhythmias. J Interv Card Electrophysiol. 2014; 39:25-35.
  • Gemmell P, Burrage K, Rodriguez B, Quinn TA. Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation. PLoS One. 2014; 28:e90112.
  • Quinn TA, Kohl P. Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies. Cardiovasc Res. 2013; 97:601-11.
  • Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RAB, Cerbai E, Chen PS, Delmar M, DiFrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding DE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PGA, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol. 2011; 107:4-10.
  • Quinn TA, Cabreriza SE, Richmond ME, Weinberg AD, Holmes JW, Spotnitz HM. Simultaneous variation of ventricular pacing site and timing with biventricular pacing during acute ventricular failure improves function by interventricular assist. Am J Physiol Heart Circ Physiol. 2009; 297:H2220-6.

Selected awards & honours

  • Fulford Junior Research Fellowship in Medical Sciences, Somerville College, University of Oxford, UK
  • Postdoctoral Research Fellowship at the Life Sciences Interface, Engineering and Physical Sciences Research Council, UK
  • Poster Competition Award, Gordon Research Conference on Cardiac Arrhythmia Mechanisms, USA
  • PhD Dissertation Distinction (top 10%), Columbia University, USA

Techniques

  • Isolated heart / tissue / cell preparations
  • Multi-scale imaging of electrical and mechanical activity
  • Fluorescent dye-based voltage / calcium optical mapping
  • Genetically-expressed voltage / calcium fluorescent reporters
  • Computational modelling

Equipment

  • Custom Langendorff-perfusion and optical mapping systems
  • High-speed, high resolution sCMOS & EMCCD fluorescence cameras
  • Upright water immersion & inverted fluorescence microscopes
  • Fluorescence macroscope
  • Custom data acquisition and instrument control systems

Biography

Dr. Quinn received his BSc in Physiology & Physics from McGill University and his MSc and PhD in Biomedical Engineering from Columbia University in New York. He did his postdoctoral work at the University of Oxford and Imperial College London, before joining the faculty of Dalhousie University in April 2013.

Services & activities

  • Deputy editor, Medical & Biological Engineering & Computing
  • Guest editor, Progress in Biophysics & Molecular Biology
  • Member, Heart and Stroke Foundation Scientific Review Committee IVa (Molecular, Biochemical and Cellular Physiological Approaches to Cardiovascular Health and Disease, Vascular Disorders)
  • External reviewer, Mitacs Elevate Postdoctoral Fellowship & Accelerate Internship Programs
  • External reviewer, Wellcome Trust Intermediate Clinical Fellowship Programme

Teaching

  • PHYL 1400: Human Physiology (Cardiovascular Physiology section)
  • PHYL 2032: Human Systems Physiology (Cardiovascular Physiology section)
  • PHYL 5508: Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management (Directed Reading)