Melina  Agosto

Assistant Professor

Physiology_Agosto

Email: melina.agosto@dal.ca
Phone: 902-706-1292
Mailing Address: 
15-A4 Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2
 
Research Topics:
  • Vision
  • Retinal neurons
  • Synaptic trafficking
  • Macromolecular protein complexes
  • Glutamate receptors
  • Signal transduction

Education

  • BS (Massachusetts Institute of Technology) 
  • Ph.D. (Harvard University) 
  • PDF (Boston Children’s Hospital) 
  • PDF (Baylor College of Medicine)

Research Interests

The goal of Dr. Agosto’s research is to understand the proteins involved in formation and function of synapses in the retina. She employs biochemical experiments and in vivo models to address questions about protein-protein interactions, membrane protein trafficking, receptor function, and synapse development. 

Selected Publications

  • Baker MR, Fan G, Seryshev AB, Agosto MA, Baker ML, Serysheva II. (2021). Cryo-EM structure of type 1 IP3R channel in a lipid bilayer. Communications Biology 4: 625.  
  • Agosto MA, Wensel TG. (2021). LRRTM4 is a member of the transsynaptic complex between rodphotoreceptors and ON bipolar cells. Journal of Comparative Neurology 529: 221–233.  
  • He F, Nichols RM, Kailasam L, Wensel TG, Agosto MA. (2019). Critical role for phosphatidylinositol-3 kinase Vps34/PIK3C3 in ON-bipolar cells. Investigative Ophthalmology & Visual Science 60: 2861-2874.  
  • Agosto MA, Anastassov IA, Wensel TG. (2018). Differential epitope masking reveals synapse-specificcomplexes of TRPM1. Visual Neuroscience 35: E001.  
  • Agosto MA, Anastassov IA, Robichaux MA, Wensel TG. (2018). A large endoplasmic reticulum-residentpool of TRPM1 in retinal ON bipolar cells. eNeuro 5: ENEURO.0143-18.2018.  
  • He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG. (2016). Phosphatidylinositol-3-phosphate islight-regulated and essential for survival in retinal rods. Scientific Reports 6: 26978. 
  • Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. (2015). Domain organization and conformational plasticity of the G protein effector, PDE6. Journal of Biological Chemistry 290: 12833-12843.  
  • Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG. (2014). Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision. Journal of Biological Chemistry 289: 27019-27033.
  • Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. (2014). The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biology 12: e1001847.